Coils, such as embolic coils, can include a substrate; and a porous material supported by the substrate. Related methods, devices, and compositions, can include: injecting a material into a container containing the coil; and forming the material into a coating that is supported by the coil and/or contacting the coil with a composition comprising a first polymer and a gelling precursor; and forming the composition into a coating that is supported by the coil.
1. A method of coating a coil, the method comprising:
injecting a material comprising a first polymer and a gelling precursor into a container containing the coil;
gelling the gelling precursor to provide a first coating on the coil, the coating comprising the first polymer and the gelled precursor;
cross-linking the first polymer in the first coating to provide a second coating on the coil, the second coating comprising the cross-linked first polymer and the gelled precursor; and
removing the gelled precursor from the second coating to provide a third coating on the coil, the third coating comprising the cross-linked first polymer having pores therein.
2. The method of claim 1 , wherein the coil is an embolic coil.
3. The method of claim 1 , wherein the first polymer comprises a polysaccharide.
4. The method of claim 1 , wherein the first polymer comprises alginate.
5. The method of claim 1 , wherein the first polymer comprises polyvinyl alcohol.
6. The method of claim 1 , wherein the material further comprises a second polymer different from the first polymer.
7. The method of claim 1 , wherein gelling the gelling precursor comprises contacting the material with a gelling agent.
8. The method of claim 7 , wherein contacting the material with the gelling agent comprises delivering the gelling agent into the container.
9. The method of claim 1 , wherein cross-linking the first polymer comprises contacting the material with a cross-linking agent.
10. The method of claim 1 , further comprising contacting the third coating with a therapeutic agent.
11. The method of claim 1 , wherein the material comprises a therapeutic agent.
12. The method of claim 1 , wherein the container comprises a tubular member.
13. The method of claim 1 , further comprising removing the coil from the container.
14. The method of claim 13 , wherein the container comprises a bioerodible or bioabsorbable material, and removing the coil from the container comprises eroding or absorbing the container.