Methods for treating or preventing skin disorders using CD2-binding agents
Methods for treating or preventing an epidermal or dermal disorder, e.g., psoriasis, using a CD2-binding agent, e.g., an inhibitor of the CD2/LFA-3 interaction (e.g., an LFA-3/IgG fusion polypeptide), in combination with an auxiliary agent, e.g., UVB irradiation, are disclosed.
1 . A method of treating, or preventing, in a subject, a epidermal or dermal disorder characterized by aberrant T cell activity or proliferation, comprising:
Administering to the subject an inhibitor of the CD2/LFA-3 interaction, in combination with an auxiliary agent,
to thereby treat or prevent said epidermal or dermal disorder.
2 . The method of claim 1 , wherein the epidermal or dermal disorder is characterized by increased T cell INFγ production.
3 . The method of claim 1 , wherein the epidermal or dermal disorder is a chronic inflammatory disorder.
4 . The method of claim 1 , wherein the epidermal or dermal disorder is an autoimmune disorder.
5 . The method of claim 1 , wherein the epidermal or dermal disorder is psoriasis.
6 . The method of claim 1 , wherein the inhibitor of the CD2/LFA-3 interaction is a CD2-binding agent.
7 . The method of claim 1 , wherein the inhibitor of the CD2/LFA-3 interaction is a CD2-binding fragment of LFA-3 fused to an immunoglobulin or a fragment thereof.
8 . The method of claim 1 , wherein the inhibitor of the CD2/LFA-3 interaction is an LFA-3/IgG fusion polypeptide.
9 . The method of claim 1 , wherein auxiliary agent is selected from the group consisting of light therapy, methotrexate, retinoids, macrolides, macrolactans, cyclosporine, and etretinate.
10 . The method of claim 1 , wherein the auxiliary agent is UVB radiation.
11 . The method of claim 1 , further comprising the step of monitoring the subject for symptoms, or for changes in cytokine levels or in an immune cell population.
12 . The method of claim 1 , further comprising the step of administering to the subject a topically applied agent selected from the group consisting of a steroid, vitamin, tar, anthralin, and macrolactam.
13 . The method of claim 1 , wherein the subject is a mammal.
14 . A method of treating, or preventing, psoriasis in a subject, comprising:
Administering to the subject a fusion polypeptide which includes a CD2-binding fragment of LFA-3 fused to a fragment of the constant region of an IgG, in combination with an amount of UVB sufficient to reduce interferon-γ levels in the epidermis of the subject, to thereby treat or prevent said psoriasis.
15 . A method of treating, or preventing, in a subject, an inflammatory disorder, comprising:
Administering to the subject an inhibitor of the CD2/LFA-3 interaction, in combination with an auxiliary agent, to thereby treat or prevent said inflammatory disorder.
16 . A method of treating, or preventing, in a subject, an autoimmune disorder, comprising:
Administering to the subject an inhibitor of the CD2/LFA-3 interaction, in combination with an auxiliary agent, to thereby treat or prevent said autoimmune disorder.
17 . The method of claim 16 , wherein the autoimmune disorder is selected from the group consisting of psoriasis, diabetes mellitus, arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, psoriatic arthritis, multiple sclerosis, encephalomyelitis, myasthenia gravis, systemic lupus erythematosis, autoimmune thyroiditis, dermatitis, atopic dermatitis and eczematous dermatitis.
18 . A method of treating, or preventing, atopic dermatitis in a subject, comprising:
Administering to the subject a fusion polypeptide which includes a CD2-binding fragment of LFA-3 fused to a fragment of the constant region of an IgG, in combination with an amount of UVB sufficient to reduce interferon-γ levels in the epidermis of the subject, to thereby treat or prevent said atopic dermatitis.