Methods and compositions for treating amyloid-related diseases
View Patent ↗Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
1. A compound of the formula (XII):
wherein:
R h is hydrogen or unsubstituted alkyl;
R i is unsubstituted C 2 -C 7 alkyl;
R j , R k , R m , R n , and R o are each independently hydrogen or unsubstituted alkyl;
X + is hydrogen, a cationic group, or an ester-forming group; and
t 1 and t 2 are each a single bond or a pharmaceutically acceptable salt, ester, or prodrug thereof.
2. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt or ester, thereof.
3. A pharmaceutical composition comprising a compound according to claim 1 .
4. A pharmaceutical composition comprising a compound selected from the group consisting of:
and a pharmaceutically acceptable carrier.
5. The compound of claim 1 , wherein R h is hydrogen.
6. The compound of claim 5 , wherein R j , R m , and R o are each hydrogen.
7. The compound of claim 5 , wherein R j , R k , R m , R n and R o are each hydrogen.
8. The compound of claim 7 , wherein R i is ethyl, propyl, butyl, pentyl, hexyl or heptyl.
9. The compound of claim 1 , wherein said compound has the structure:
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 9 , wherein said compound has the structure:
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 9 , wherein said compound has the structure:
or a pharmaceutically acceptable salt thereof.