Phthalazinone derivatives
View Patent ↗Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR X or CR X R Y ; if X=NR X then n is 1 or 2 and if X=CR X R Y then n is 1; R X is selected from the group consisting of H, optionally substituted C 1-20 alkyl, C 5-20 aryl, C 3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; R Y is selected from H, hydroxy, amino; or R X and R Y may together form a spiro-C 3-7 cycloalkyl or heterocyclyl group; R C1 and R C2 are both hydrogen, or when X is CR X R Y , R C1 , R C2 , R X and R Y , together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R 1 is selected from H and halo.
1. A compound of the formula (I):
or an isomer thereof, or a salt thereof, wherein: A and B together represent an optionally substituted, fused aromatic ring;
X is CR X R Y ;
n is 1;
R X is selected from hydrogen, optionally substituted C 1-20 alkyl, optionally substituted C 5-20 aryl, optionally substituted C 3-20 heterocyclyl, optionally substituted amido, optionally substituted thioamido, optionally substituted ester, optionally substituted acyl, and optionally substituted sulfonyl groups;
R Y is selected from hydrogen, hydroxy, and amino;
or R X and R Y may together form a spiro-C 3-7 cycloalkyl or heterocyclyl group;
R C1 and R C2 are both hydrogen, or R C1 , R C2 , R X and R Y together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and
R 1 is selected from hydrogen and halo.
2. A compound according to claim 1 , wherein the fused aromatic ring(s) represented by -A-B— consist of solely carbon ring atoms.
3. A compound according to claim 2 , wherein the fused aromatic ring represented by -A-B— is benzene.
4. A compound according to claim 1 , wherein R 1 is selected from hydrogen, Cl and F.
5. A compound according to claim 1 , wherein R C1 and R C2 are both hydrogen.
6. A compound according to claim 1 , wherein R Y is hydrogen, and R X is selected from hydrogen; optionally substituted C 1-20 alkyl; optionally substituted C 5-20 aryl; optionally substituted C 3-20 heterocyclyl; optionally substituted acyl; optionally substituted amido; and optionally substituted ester groups.
7. A pharmaceutical composition comprising a compound according to claim 1 and one or more pharmaceutically acceptable carriers, excipients, buffers, adjuvants, or stabilisers.