Aptamer therapeutics useful in the treatment of complement-related disorders

1. An aptamer comprising:

wherein fC and fU=2′-fluoro nucleotides, mG and mA=2′-OMe nucleotides, all other nucleotides are 2′-OH, and 3T indicates an inverted thymidine cap.

2. The aptamer of claim 1 , wherein the linker is an alkyl linker.

3. The aptamer of claim 2 , wherein the alkyl linker comprises 2 to 18 consecutive CH 2 groups.

4. The aptamer of claim 3 , wherein the alkyl linker comprises 2 to 12 consecutive CH 2 groups.

5. The aptamer of claim 4 , wherein the alkyl linker comprises 3 to 6 consecutive CH 2 groups.

6. The aptamer of claim 2 , wherein the alkyl linker comprises 6 consecutive CH 2 groups.

7. An aptamer comprising:

wherein fC and fU=2′-fluoro nucleotides, and mG and mA=2′-OMe nucleotides and all other nucleotides are 2′-OH and 3T indicates an inverted deoxy thymidine.