IP Library › Patent Application 11319178
Patent Application
App. No. 11/319,178

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Quick Facts
Patent No.
US None
App. No.
11/319,178
Abstract

This invention relates to a new use of a compound of the following formula (I) or (II) for the manufacture of a medicament for preventing and/or treating chronic rejection in a transplanted organ or tissue.

Claims (21)

1 . A method for preventing and/or treating chronic rejection in a transplanted organ or tissue, which comprises administering a therapeutically effective amount of compound of the formula (I) or (II):

to a mammalian recipient in need thereof.

2 . The method of claim 1 wherein the method is for preventing chronic rejection.

3 . The method of claim 2 wherein the transplantation is allograft transplantation.

4 . The method of claim 1 further comprising administering a therapeutically effective amount of tacrolimus.

5 . The method of claim 3 further comprising administering a therapeutically effective amount of tacrolimus.

6 . The method of claim 1 wherein the method is in oral administration.

7 . A use of a compound of the formula (I) or (II):

for the manufacture of a medicament for preventing and/or treating chronic rejection in a transplanted organ or tissue.

8 . The use of claim 7 wherein the medicament is for preventing chronic rejection.

9 . The use of claim 8 wherein the transplantation is allograft transplantation.

10 . The use of claim 7 for the manufacture of the medicament with tacrolimus.

11 . The use of claim 9 for the manufacture of the medicament with tacrolimus.

12 . The use of claim 7 wherein the medicament is for oral administration.

13 . A pharmaceutical composition for preventing and/or treating chronic rejection in a transplanted organ or tissue, which comprises a therapeutically effective amount of compound of the formula (I) or (II):

in admixture with a pharmaceutically acceptable carrier or excipient.

14 . The pharmaceutical composition of claim 13 wherein the composition is for preventing chronic rejection.

15 . The pharmaceutical composition of claim 14 wherein the transplantation is allograft transplantation.

16 . The pharmaceutical composition of claim 13 which is for co-administering a therapeutically effective amount of tacrolimus.

17 . The pharmaceutical composition of claim 15 which is for co-administering a therapeutically effective amount of tacrolimus.

18 . The pharmaceutical composition of claim 13 which is for oral administration.