Treatment of neurological disorders with nicotine
Neurological disorders, such as migraine and addiction to smoking tobacco, are treated by the administration of an effective amount of nicotine, preferably in a water solution of nicotine processed to diminish the odor, taste, and smell of nicotine.
1 . A method for treating a patient subject to migraine headaches, the method comprising administering to the patient an effective amount of nicotine.
2 . A method according to claim 1 in which the nicotine is in water at a concentration between about 0.4 and about 15 mg of nicotine per 250 ml of solution.
3 . A method according to claim 1 or 2 in which the nicotine is administered to the patient at a rate to cause the nicotine level of the patient to reach between about 1 and about 10 nanograms in a per milliliter of blood.
4 . A method according to claim 1 in which the nicotine is administered in the form of a beverage, nasal spray, tablet, gel cap, transdermal patch, gum, or by injection.
5 . A method according to claim 1 or 2 in which the total amount of nicotine administered to the patient per 24 hour period is between about 1 and about 50 mg
6 . A process for preparing a beverage treated with nicotine, the process including the steps of:
a) stirring a mixture of nicotine and water at a temperature above about 40° C. for at least about one minute;
b) filtering the mixture; and
c) adding the filtrate from the mixture to additional water to produce the beverage.
7 . A process for preparing a beverage treated with nicotine, the process including the steps of:
a) stirring a mixture of nicotine and water at a temperature above about 75° C. for at least one minute;
b) cooling the mixture to below about 50° C.;
c) filtering the cooled mixture; and
d) adding the filtrate from the mixture to additional water to produce the beverage.
8 . A process according to claim 6 or 7 in which:
a) the water and nicotine mixture is stirred for at least five minutes at a temperature about 100° C.; and thereafter
b) cooled to about room temperature before filtering.
9 . A process according to claim 6 or 7 in which the nicotine is in the form of substantially pure nicotine.
10 . A process according to claim 7 in which the nicotine is in the form of nicotine polacrilex.
11 . A process according to claim 6 or 7 in which the mixture is stirred and boiled at about 100° C. for at least about five minutes during the heating step.
12 . A process according to claim 6 or 7 in which the mixture is stirred and boiled for at least about thirty minutes.
13 . A process according to claim 6 or 7 in which the filtering step includes filtering the mixture through activated carbon.
14 . A process according to claim 6 or 7 in which the concentration of the nicotine in the heated and stirred mixture is at least about 20 mg in 250 ml of water.
15 . A process according to claim 6 or 7 in which the concentration of the nicotine in the beverage after mixing the filtrate with the additional water is between about 0.5 and 20 mg in 250 ml of water.
16 . A process according to claim 6 or 7 in which the filtering step includes filtering the mixture through a permeable membrane having an effective pore size below about 1 micron.
17 . A processing according to claim 16 which includes applying a pressure of more than about 5 pounds per square inch to force liquid from the mixture through the membrane.
18 . A process according to claim 6 or 7 in which the concentration of the nicotine in the heated and stirred mixture is between about 8% and about 10% by weight.