Implantable aneurysm closure systems and methods
An implantable closure structure is delivered using minimally invasive techniques and inhibits the migration of liquid and particulate matter from inside a physiological cavity or opening, such as an aneurysm, as well as inhibiting the flow of liquid and particulate matter, such as from an associated blood vessel, into a physiological cavity or opening. The device has a flexible patch supported by a framework structure that covers the neck or opening of a cavity such as an aneurysm and may have anchoring structures for supporting the flexible patch in place across the opening.
1. An implantable aneurysm closure device adjustable from a delivery arrangement in which the device has a generally small diameter configuration to a deployed arrangement in which the device has a larger diameter configuration, the implantable aneurysm closure device comprising:
a tapered closure structure having a generally truncated conical configuration, wherein the closure structure comprises an open distal end and is configured to contact at least a portion of an internal wall of an aneurysm when the device is in the deployed arrangement;
a closure membrane having a first major surface and a second major surface opposite the first surface, wherein the first surface is coupled with a base of the tapered closure structure, and wherein the closure membrane is sized to substantially cover an opening of the aneurysm when the device is in the deployed arrangement; and
an anchoring structure comprising at least two positioning members extending away from the closure membrane and biased toward the tapered closure structure, and wherein, in the deployed arrangement, the at least two positioning members are configured to reside outside the aneurysm and extend generally beyond a periphery of the closure membrane.
2. The implantable aneurysm closure device of claim 1 wherein the tapered closure structure comprises a discontinuous mesh structure constructed from a shape change material.
3. The implantable aneurysm closure device of claim 1 wherein the tapered closure structure is covered, at least in part, with a flexible membrane material.
4. The implantable aneurysm closure device of claim 1 wherein the tapered closure structure is associated with the closure membrane at a smaller diameter base portion, and wherein the closure membrane extends beyond the smaller diameter base portion of the tapered closure structure.
5. The implantable aneurysm closure device of claim 1 wherein a larger perimeter end of the tapered closure structure opposite the base portion including an opening having a diameter larger than that of the base portion.
6. The implantable aneurysm closure device of claim 1 wherein the tapered closure structure is configured to contact only a proximal portion of the internal wall of the aneurysm when the device is in the deployed arrangement.
7. The implantable aneurysm closure device of claim 1 wherein the at least two positioning members, in the deployed arrangement, are configured to be biased toward an inner wall of a blood vessel in proximity to the aneurysm.
8. The implantable aneurysm closure device of claim 1 wherein the at least two positioning members comprise wire loops.
9. The implantable aneurysm closure device of claim 1 wherein the closure structure comprises a substantially continuous occlusive surface area.
10. The implantable aneurysm closure device of claim 1 wherein the closure structure is composed of a material that is substantially impermeable to fluids.
11. The implantable aneurysm closure device of claim 1 wherein the closure structure is composed of a material that is semi-permeable or permeable to fluids and allows at least limited exchange of fluids across the structure.
12. The implantable aneurysm closure device of claim 1 wherein the at least two positioning members comprise a first positioning member and a second positioning member having at least approximately identical configurations.
13. The implantable aneurysm closure device of claim 1 wherein the at least two positioning members comprise a first positioning member and a second positioning member having different configurations.
14. The implantable aneurysm closure device of claim 1 wherein the at least two positioning members comprise a first positioning member extending in a first direction from the closure membrane, and a second positioning member extending in a second, opposite direction from the closure membrane.
15. The implantable aneurysm closure device of claim 1 wherein the at least two positioning members are composed of a biocompatible shape memory alloy material.
16. The implantable aneurysm closure device of claim 1 wherein the closure membrane comprises a generally cylindrical structure extending in a plane generally orthogonal to that of the tapered closure structure in the deployed arrangement.
17. The implantable aneurysm closure device of claim 1 wherein the at least two positioning members are discrete, independent components coupled to the second surface of the closure membrane.