IP Library Granted Patent US 7,161,042
Granted Patent B2
US 7,161,042 · App. 11/327,876 · Granted Jan 9, 2007

Protected diols for prostaglandin synthesis

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Quick Facts
Patent No.
US 7,161,042
App. No.
11/327,876
Granted
Jan 9, 2007
Kind
B2
Abstract

A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C 1 –C 6 alkyl groups; C 7 –C 16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C 1 –C 6 alkyl groups, halo and CF 3 ; and (CH 2 ) n OR′ wherein n is an integer from 1 to 3 and R′ represents a C 6 –C 10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C 1 –C 6 alkyl groups, halo and CF 3 ; B is selected from OR″ and NHR″ wherein R″ is C 1 –C 6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

Claims (9)

1. A compound according to formula (VIII):

wherein A is (CH 2 ) 2 Ph or CH 2 OR′″ wherein R′″ is meta-trifluoromethylphenyl, P is a hydroxyl protecting group, and is a double bond or a single bond.

2. The compound according to claim 1 , wherein A is (CH 2 ) 2 Ph.

3. The compound according to claim 2 , wherein is a double bond.

4. The compound according to claim 2 , wherein is a single bond.

5. The compound according to claim 1 , wherein A is CH 2 OR′″.

6. The compound according to claim 5 , wherein is a double bond.

7. The compound according to claim 5 , wherein is a single bond.

8. The compound according to claim 1 , wherein P is a tetrahydropyranyl group.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2022
From: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
To: MACFARLAN SMITH LIMITED
Reel/Frame 061888/0166 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 29, 2022
From: CLISSOLD, DEREK WYNDHAM; CRAIG, STUART WILBERT; GADIKOTA, RAJENDRAKUMAR REDDY; HE, MIN; JURAYJ, JURJUS FAYEZ; KAZERANI, SHAHROKH; RANNALA, ERWIN; SHARMA, PRADEEP KUMAR
To: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
Reel/Frame 059714/0217 →