IP Library Granted Patent US 8,090,424
Granted Patent B2
US 8,090,424 · App. 11/330,406 · Granted Jan 3, 2012

Method and apparatus for glucose level detection

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Quick Facts
Patent No.
US 8,090,424
App. No.
11/330,406
Granted
Jan 3, 2012
Kind
B2
Abstract

An apparatus for determine a glucose level having a calibration module; an image acquisition module; an image compensation module; and, a dynamic pattern matching module. A method using the apparatus is also described.

Claims (35)

1. An apparatus for determining a glucose level of an individual, comprising:

a processor configured to execute modules comprising:

a calibration module configured to produce a calibration table created by analyzing a plurality of portions of Newton's Rings in images from a calibration eye at multiple wavelengths obtained at various glucose levels, using first base image parameters, said calibration module configured to store said calibration table in a storage medium;

an image acquisition module configured to receive captured images of a plurality of portions of Newton's Rings in an eye of said individual at said multiple wavelengths from means for capturing images, using second base image parameters that approximate said first base image parameters;

an image compensation module for compensating the captured images for differences between said base image parameters; and

a dynamic pattern matching module for comparing points on said plurality of portions of Newton's Rings from said compensated captured images to corresponding points in said calibration table at said multiple wavelengths to determine various possible concentration values for each wavelength, and for determining one common answer from the various possible concentration values as said glucose level of said individual.

2. An apparatus according to claim 1 , further comprising at least one light source providing light at multiple wavelengths selected from the group consisting of lasers, light emitting diodes, sodium lights, extended light sources, and light with filters.

3. An apparatus according to claim 1 , wherein said points comprise L “L” shaped phase detector areas.

4. An apparatus according to claim 1 , wherein said processor controls operation of a client, and said client further comprises a display to display content and information, a camera to capture images, an illumination system for illuminating said individual's eye, and a memory for storing data and programs related to the operation of the client, wherein the means for capturing images is the camera.

5. An apparatus according to claim 4 , wherein said client has a communication interface means for communicating with said processor.

6. An apparatus according to claim 4 , wherein said client is selected from the group consisting of a handheld computer, a personal computer, a cellular phone, and an eye diagnostic device having a communication interface.

7. An apparatus according to claim 1 , wherein said processor is selected from the group consisting of a general purpose processor, an application specific integrated circuit, a digital signal processor, a programmable logic device, a microprocessor, a controller, a state machine, and an eye diagnostic device.

8. An apparatus according to claim 1 , wherein said storage medium is integral to said processor.

9. An apparatus according to claim 1 , wherein said calibration eye is selected from the group consisting of a surrogate eye and an eye of said individual.

10. The apparatus according to claim 1 , wherein the portions of Newton's Rings comprise ring bundles.

11. A method for determining a glucose level of an individual, comprising:

calibrating intensity determinations of a plurality of portions of Newton's Rings in an eye with various glucose concentrations at multiple wavelengths;

lighting said individual's eye with a light source to create portions of Newton's Rings at said multiple wavelengths;

capturing captured images of a plurality of portions of Newton's Rings in said individual's eye at said multiple wavelengths;

processing the captured images to compensate for image capturing deviations between said calibrating step and said capturing step; and

determining various possible glucose concentrations based on intensity determinations of a plurality of portions of Newton's Rings in the processed captured images and the calibration results at said multiple wavelengths, and determining one common answer from the various possible glucose concentrations as said glucose level of said individual.

12. A process according to claim 11 , wherein said calibrating step and said capturing step are performed at the same multiple wavelengths.

13. A process according to claim 11 , wherein said lighting and capturing steps are performed with simultaneous multiple wavelengths.

14. A process according to claim 11 , wherein said calibrating step is performed by calibrating said intensity determinations with various glucose concentrations in an eye selected from the group consisting of an eye of said individual and a surrogate eye.

15. The process according to claim 11 , wherein the portions of Newton's Rings comprise ring bundles.

16. An apparatus for determining a glucose level of an individual having an eye, comprising:

a storage medium capable of containing a calibration table for said individual, said calibration table created by imaging a plurality of portions of Newton's Rings in said eye at multiple wavelengths and various glucose levels of said individual, using first base image parameters and said apparatus configured to store said calibration table in said storage medium prior to determining a glucose level of said individual;

a light source for lighting said eye at said multiple wavelengths to create portions of Newton's Rings;

an image capture device for capturing captured images of a plurality of portions of Newton's Rings in said eye at said multiple wavelengths using second base image parameters that approximate said first base image parameters;

an image processor connected to said storage medium and said image capture device for compensating said captured images for differences between said base image parameters; and

a dynamic pattern matcher connected to said image processor for comparing points on said compensated captured images of a plurality of portions of Newton's Rings to corresponding points in said calibration table at said multiple wavelengths to determine various possible concentration values for each wavelength, and for determining one common answer from the various possible concentration values as said glucose level of said individual.

17. An apparatus according to claim 16 , wherein said points comprise “L” shaped phase detector areas.

18. An apparatus according to claim 16 , wherein said points comprise “L” shaped phase detector areas defining an X area and a Y area, and said dynamic pattern matcher compares points by using the ratio Y/X of said phase detector areas or tracking the amplitude Y+X of said phase detector areas.

19. The apparatus according to claim 16 , wherein the portions of Newton's Rings comprise ring bundles.

20. An apparatus according to claim 16 , wherein said dynamic pattern matcher compares points by applying a Fourier transform.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 24, 2010
From: Q STEP TECHNOLOGIES, INC.
To: STI MEDICAL SYSTEMS, LLC
Reel/Frame 024434/0073 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 28, 2008
From: WINTHER, DALE E.; WANG, LIMING; ZHAO, RUNCHUAN
To: Q STEP TECHNOLOGIES, INC.
Reel/Frame 021298/0530 →