Arylsulfonamidobenzylic compounds

1. A compound having the formula:

wherein

R 1 is

wherein

R 11 is a member selected from the group consisting of phenyl, pyridyl, pyridazinyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, tetrazolyl, indolyl, benzimidazolyl, benzothienyl and benzothiazolyl, each of said R 11 groups being optionally substituted with from one to five substituents independently selected from the group consisting of halogen, cyano, nitro, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, (C 1 -C 8 )haloalkyl, phenyl(C 1 -C 6 )alkyl and phenyl(C 2 -C 6 )heteroalkyl;

X is OH; and

Y is fluoro(C 1 -C 4 )alkyl;

R 2 is a member selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, (C 3 -C 8 )alkenyl, (C 3 -C 8 )alkynyl, (C 3 -C 8 )cycloalkyl and (C 4 -C 8 )cycloalkyl-alkyl, wherein any alkyl portions of R 2 are optionally substituted with from one to three substituents independently selected from halogen, nitro, cyano, hydroxy, oxo and amino, or optionally R 2 is combined with R 4 to form a five- to six-membered fused ring containing from 1 to 3 heteroatoms selected from the group consisting of N, O and S;

R 3 is a member selected from the group consisting of aryl and heteroaryl, said aryl or heteroaryl group being optionally substituted with from one to five substituents independently selected from the group consisting of halogen, cyano, nitro, R 16 , OR 16 , SR 16 , COR 16 , CO 2 R 16 , NHR 16 , N(R 16 ) 2 , CONHR 16 , CON(R 16 ) 2 , NHSO 2 R 16 , NHC(O)R 16 , phenyl, phenyl(C 1 -C 8 )alkyl, and phenyl(C 2 -C 8 )heteroalkyl; wherein each R 16 is independently selected from (C 1 -C 8 )alkyl, (C 3 -C 8 )alkenyl, (C 3 -C 8 )alkynyl, (C 2 -C 8 )heteroalkyl and halo(C 1 -C 8 )alkyl, or two R 16 groups attached to the same nitrogen atom are combined to form a five- to eight-membered ring;

the subscript n is an integer of from 0 to 3; and

each R 4 is independently selected from the group consisting of halogen, cyano, nitro, R 17 , OR 17 , SR 17 , COR 17 , CO 2 R 17 , N(R 17 ) 2 and CON(R 17 ) 2 , wherein each R 17 is independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 8 )alkenyl, (C 3 -C 8 )alkynyl, (C 2 -C 8 )heteroalkyl and halo(C 1 -C 8 )alkyl, or two R 17 groups attached to the same nitrogen atom are combined to form a five- to eight-membered ring; and pharmaceutically acceptable salts thereof.

2. A compound of claim 1 , wherein R 11 is phenyl, optionally substituted with from one to two substituents independently selected from the group consisting of halogen, cyano, nitro, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, (C 1 -C 8 )haloalkyl, phenyl(C 1 -C 6 )alkyl and phenyl(C 2 -C 6 )hetroalkyl.

3. A compound of claim 2 , wherein R 2 is a member selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl and (C 4 -C 8 )cycloalkyl-alkyl, wherein any alkyl portions of R 2 are optionally substituted with from one to three substituents independently selected from halogen, nitro, cyano, hydroxy, oxo and amino.

4. A compound of claim 3 , wherein R 3 is a member selected from the group consisting of phenyl, pyridyl, thienyl and thiazolyl, optionally substituted with from one to five substituents independently selected from the group consisting of halogen, cyano, nitro, R 16 , OR 16 , SR 16 , COR 16 , CO 2 R 16 , NHR 16 , N(R 16 ) 2 , CONHR 16 , CON(R 16 ) 2 , NHSO 2 R 16 , NHC(O)R 16 , phenyl, phenyl(C 1 -C 8 )alkyl, and phenyl(C 2 -C 8 )heteroalkyl; wherein each R 16 is independently selected from (C 1 -C 8 )alkyl, (C 3 -C 8 )alkenyl, (C 3 -C 8 )alkynyl, (C 2 -C 8 )heteroalkyl and halo(C 1 -C 8 )alkyl, or two R 16 groups attached to the same nitrogen atom are combined to form a five- to eight-membered ring.

5. A compound of claim 4 , wherein the subscript n is an integer of from 0 to 2, and each R 4 is independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl and halo(C 1 -C 8 )alkyl.

6. A compound of claim 1 , wherein R 11 is pyrrolyl, optionally substituted with from one to two substituents independently selected from the group consisting of halogen, cyano, nitro, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, (C 1 -C 8 )haloalky, phenyl(C 1 -C 6 )alkyl and phenyl(C 2 -C 6 )hetroalkyl.

7. A compound of claim 6 , wherein R 2 is a member selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl and (C 4 -C 8 )cycloalkyl-alkyl, wherein any alkyl portions of R 2 are optionally substituted with from one to three substituents independently selected from halogen, nitro, cyano, hydroxy, oxo and amino.

8. A compound of claim 7 , wherein R 3 is a member selected from the group consisting of phenyl, pyridyl, thienyl and thiazolyl, optionally substituted with from one to five substituents independently selected from the group consisting of halogen, cyano, nitro, R 16 , OR 16 , SR 16 , COR 16 , CO 2 R 16 , NHR 16 , N(R 16 ) 2 , CONHR 16 , CON(R 16 ) 2 , NHSO 2 R 16 , NHC(O)R 16 , phenyl, phenyl(C 1 -C 8 )alkyl, and phenyl(C 2 -C 8 )heteroalkyl; wherein each R 16 is independently selected from (C 1 -C 8 )alkyl, (C 3 -C 8 )alkenyl, (C 3 -C 8 )alkynyl, (C 2 -C 8 )heteroalkyl and halo(C 1 -C 8 )alkyl, or two R 16 groups attached to the same nitrogen atom are combined to form a five- to eight-membered ring.

9. A compound of claim 8 , wherein the subscript n is an integer of from 0 to 2, and each R 4 is independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl and halo(C 1 -C 8 )alkyl.