Pharmaceutical composition containing 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol with delayed active ingredient release
Pharmaceutical compositions with delayed release which contains 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a pharmaceutically acceptable salt thereof in a matrix with delayed active ingredient release, wherein the matrix contains 1 to 80 wt. % of one or more hydrophilic or hydrophobic polymers as pharmaceutically acceptable matrix formers and exhibits the following in vitro release rate: 3-35 wt. % (relative to 100 wt. % of active ingredient) of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol released after 0.5 hours, 5-50 wt. % after 1 hour, 10-75 wt. % after 2 hours, 15-82 wt. % after 3 hours, 30-97 wt. % after 6 hours, more than 50 wt. % after 12 hours, more than 70 wt. % after 18 hours, and more than 80 wt. % after 24 hours.
1 . A delayed-release pharmaceutical composition comprising as active ingredient 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a pharmaceutically acceptable salt thereof in a delayed-release matrix,
wherein the matrix comprises 1 to 80 wt. % of at least pharmaceutically acceptable matrix forming polymer, and
wherein the pharmaceutical composition releases in vitro
3-35 wt. % of the active ingredient after 0.5 hours,
5-50 wt. % of the active ingredient after 1 hour,
10-75 wt. % of the active ingredient after 2 hours,
15-82 wt. % of the active ingredient after 3 hours,
30-97 wt. % of the active ingredient after 6 hours,
more than 50 wt. % of the active ingredient after 12 hours,
more than 70 wt. % of the active ingredient after 18 hours, and
more than 80 wt. % of the active ingredient after 24 hours,
as measured using a Ph. Eur. paddle method at 75 rpm in a buffer at a pH value of 6.8 at 37° C. and with detection by UV spectrometry.
2 . A pharmaceutical composition according to claim 1 , wherein the pharmaceutically acceptable matrix former comprises cellulose ethers, or cellulose esters, or both, which exhibit a viscosity in a 2 wt. % aqueous solution at 20° C. of from 10,000 to 150,000 mPa·s.
3 . A pharmaceutical composition according to claim 2 , wherein the pharmaceutically acceptable matrix former comprises cellulose ethers, or cellulose esters, or both, which exhibit a viscosity in a 2 wt. % aqueous solution at 20° C. of from 50,000 to 150,000 mPa·s.
4 . A pharmaceutical composition according to claim 1 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises at least one substance selected from the group consisting of hydroxypropylmethylcelluloses, hydroxyethylcelluloses, hydroxypropylcelluloses, methylcelluloses, ethylcelluloses and carboxymethylcelluloses.
5 . A pharmaceutical composition according claim 4 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises at least one substance selected from the group consisting of hydroxypropylmethylcelluloses, hydroxyethylcelluloses and hydroxypropylcelluloses.
6 . A pharmaceutical composition according to claim 1 , wherein the content of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or salt thereof is between 0.5 and 85 wt. % and the content of the at least one pharmaceutically acceptable matrix forming polymer is between 8 and 40 wt. %.
7 . A pharmaceutical composition according to claim 6 , wherein the content of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or salt thereof is between 3 and 70 wt. %, and the content of the at least one pharmaceutically acceptable matrix forming polymer is between 10 and 35 wt. %.
8 . A pharmaceutical composition according to claim 7 , wherein the content of he content of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or salt thereof is between 8 and 66 wt. %, and the content of the at least one pharmaceutically acceptable matrix forming polymer is between 10 and 30 wt. %.
9 . A pharmaceutical composition according to claim 1 , comprising (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a pharmaceutically acceptable salt thereof.
10 . A pharmaceutical composition according to claim 1 , comprising 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol as a racemic mixture, or as a mixture of stereoisomers thereof in any mixing ratio, in each case as the free base or in the form of a pharmaceutically acceptable salt.
11 . A pharmaceutical composition according to claim 1 , comprising a pure stereoisomer of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol, as the free base or in the form of a pharmaceutically acceptable salt.
12 . An oral tablet comprising a pharmaceutical composition of claim 1 which provides effective administration of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol for 12 hours.
13 . An oral tablet comprising a pharmaceutical composition of claim 1 which provides effective administration of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol for 24 hours.
14 . A delayed-release pharmaceutical composition comprising as active ingredient 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a pharmaceutically acceptable salt thereof in a delayed-release matrix,
wherein the matrix comprises 1 to 80 wt. % of at least one pharmaceutically acceptable matrix forming polymer, and
wherein the pharmaceutical composition releases in vitro
3-60 wt. % of the active ingredient after 0.5 hours,
5-70 wt. % of the active ingredient after 1 hour,
10-75 wt. % of the active ingredient after 2 hours,
15-82 wt. % of the active ingredient after 3 hours,
30-97 wt. % of the active ingredient after 6 hours,
more than 50 wt. % of the active ingredient after 12 hours,
more than 70 wt. % of the active ingredient after 18 hours, and
more than 80 wt. % of the active ingredient after 24 hours,
as measured using a Ph. Eur. paddle method at 75 rpm in a buffer at a pH value of 6.8 at 37° C. and with detection by UV spectrometry.
15 . A pharmaceutical composition according to claim 14 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises cellulose ethers, or cellulose esters, or both, which exhibit a viscosity in a 2 wt. % aqueous solution at 20° C. of from 10,000 to 150,000 mPa·s.
16 . A pharmaceutical composition according to claim 15 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises cellulose ethers, or cellulose esters, or both, which exhibit a viscosity in a 2 wt. % aqueous solution at 20° C. of from 50,000 to 150,000 mPa·s.
17 . A pharmaceutical composition according to claim 14 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises at least one substance selected from the group consisting of hydroxypropylmethylcelluloses, hydroxyethylcelluloses, hydroxypropylcelluloses, methylcelluloses, ethylcelluloses and carboxymethylcelluloses.
18 . A pharmaceutical composition according claim 17 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises at least one substance selected from the group consisting of hydroxypropylmethylcelluloses, hydroxyethylcelluloses and hydroxypropylcelluloses.
19 . A pharmaceutical composition according to claim 14 , wherein the content of 6-dimethylaminomethyl diol or salt thereof is between 0.5 and 85 wt. % and the content of pharmaceutically acceptable matrix former is between 8 and 40 wt. %.
20 . A pharmaceutical composition according to claim 19 , wherein the content of 6-dimethylaminomethyl is between 3 and 70 wt. %, and the content of the at least one pharmaceutically acceptable matrix forming polymer is between 10 and 35 wt. %.
21 . A pharmaceutical composition according to claim 20 , wherein the content of 6-dimethylaminomethyl is between 8 and 66 wt. %, and the content of the at least one pharmaceutically acceptable matrix forming polymer is between 10 and 30 wt. %.
22 . A pharmaceutical composition according to claim 14 , comprising (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a pharmaceutically acceptable salt thereof.
23 . A pharmaceutical composition according to claim 14 , comprising 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol as a racemic mixture, or as a mixture of stereoisomers thereof in any mixing ratio, or as a pure stereoisomer thereof, in each case as the free base or in the form of a pharmaceutically acceptable salt.
24 . A pharmaceutical composition according to claim 14 , comprising a pure stereoisomer of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol, as the free base or in the form of a pharmaceutically acceptable salt.
25 . An oral tablet comprising a pharmaceutical composition of claim 14 which provides effective administration of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol for 12 hours.
26 . An oral tablet comprising a pharmaceutical composition of claim 14 which provides effective administration of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cy-clohexane-1,3-diol for 24 hours.
27 . A delayed-release pharmaceutical composition comprising as active ingredient 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a pharmaceutically acceptable salt thereof in a delayed-release matrix, wherein the matrix comprises 1 to 80 wt. % of at least one pharmaceutically acceptable matrix forming polymer, wherein the at least one pharmaceutically acceptable matrix forming polymer comprises cellulose ethers, or cellulose esters, or both, which exhibit a viscosity in a 2 wt. % aqueous solution at 20° C. of from 3,000 to 150,000 mPa·s.
28 . A pharmaceutical composition according to claim 27 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises cellulose ethers, or cellulose esters, or both, which exhibit a viscosity in a 2 wt. % aqueous solution at 20° C. of from 10,000 to 150,000 mPa·s.
29 . A pharmaceutical composition according to claim 28 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises cellulose ethers, or cellulose esters, or both, which exhibit a viscosity in a 2 wt. % aqueous solution at 20° C. of from 50,000 to 150,000 mPa·s.
30 . A pharmaceutical composition according to claim 29 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises at least one substance selected from the group consisting of hydroxypropylmethylcelluloses, hydroxyethylcelluloses, hydroxypropylcelluloses, methylcelluloses, ethylcelluloses and carboxymethylcelluloses.
31 . A pharmaceutical composition according claim 30 , wherein the at least one pharmaceutically acceptable matrix forming polymer comprises at least one substance selected from the group consisting of hydroxypropylmethylcelluloses, hydroxyethylcelluloses and hydroxypropylcelluloses.
32 . A pharmaceutical composition according to claim 27 , wherein the content of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or salt thereof is between 0.5 and 85 wt. % and the content of the at least one pharmaceutically acceptable matrix forming polymer is between 8 and 40 wt. %.
33 . A pharmaceutical composition according to claim 32 , wherein the content of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol is between 3 and 70 wt. %, and the content of pharmaceutically acceptable matrix forming polymer is between 10 and 35 wt. %.
34 . A pharmaceutical composition according to claim 33 , wherein the content of 6-dimethylaminomethyl diol is between 8 and 66 wt. %, and the content of pharmaceutically acceptable matrix forming polymer is between 10 and 30 wt. %.
35 . A pharmaceutical composition according to claim 27 , comprising (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a pharmaceutically acceptable salt thereof.
36 . A pharmaceutical composition according to claim 27 , comprising 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol as a racemic mixture, or as a mixture of stereoisomers thereof in any desired mixing ratio, or as a pure stereoisomer thereof, in each case as the free base or in the form of a pharmaceutically acceptable salt.
37 . A pharmaceutical composition according to claim 27 , comprising a pure stereoisomer of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol, as the free base or in the form of a pharmaceutically acceptable salt.
38 . An oral tablet comprising a pharmaceutical composition of claim 27 which provides effective administration of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol for 12 hours.
39 . An oral tablet comprising a pharmaceutical composition of claim 27 which provides effective administration of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol for 24 hours.