Chromatography columns
View Patent ↗A chromatography column is prepared with a stationary phase comprising a deuterated poly(ethyleneglycol), or other deuterated polymer. Formation of the stationary phase can be performed using exactly the same methodology as used when forming a stationary phase with the equivalent non-deuterated polymer. The deuterated poly(ethyleneglycol), or other deuterated polymer, preferably has increased thermal stability as compared to non-deuterated poly(ethyleneglycol), or equivalent non-deuterated polymer. This reduces bleeding of the stationary phase during gas chromatography and allows the use of greater operating temperatures.
1. A gas chromatography column having a stationary phase comprising a polymer, which comprises a plurality of component units arranged contiguously with one another, each one of the component units having a structure in accordance with the formula:
wherein each one of the —R groups is selected from the group consisting of hydrogen (—H) and deuterium (-D), and wherein at least 90% of the —R groups are deuterium so that the thermal stability of the polymer is greater than would be the case if substantially all the —R groups were hydrogen.
2. The column according to claim 1 , wherein the plurality of component units comprises a first subset of the component units for which the structure is:
and a second subset of the component units for which the structure is:
3. The column according to claim 2 , wherein the polymer is substantially a copolymer of the component units:
and
wherein N+M is from about 20 to about 20,000.
4. The column according to claim 1 , wherein at least 98% of the —R groups are deuterium.
5. The column according to claim 1 , wherein the polymer is a poly(ethyleneglycol) which is at least partially deuterated.
6. The column according to claim 1 , wherein the polymer comprises at least one chain of poly(ethyleneglycol) wherein the number of atoms of deuterium in the at least one chain as a percentage of the number of atoms of deuterium plus hydrogen in the at least one chain is at least 90%.
7. The column according to claim 6 , wherein the number of atoms of deuterium in the at least one chain as a percentage of the number of atoms of deuterium plus hydrogen in the at least one chain is at least 98%.
8. The column according to claim 1 , wherein the polymer is a straight chain polymer.
9. The column according to claim 1 , wherein the polymer is a branched chain polymer or a multi arm polymer.
10. The column according to claim 1 , wherein the polymer has a molecular weight of from 1000 to 1,000,000 in its uncross-linked form.
11. The column according to claim 1 , wherein the column is a wall coated open tubular (WCOT) column.
12. The column according to claim 1 , wherein the column includes a fused silica capillary within which the stationary phase is provided.
13. The column according to claim 1 , wherein the column includes a metal capillary within which the stationary phase is provided.
14. The column according to claim 1 , wherein the polymer is cross-linked.