Anti-inflammatory medicaments

1. A method of modulating the activation state of p38 α-kinase comprising the step of contacting said kinase with a molecule having the formula

wherein:

R 1 is selected from the group consisting of

each R 2 is individually selected from the group consisting of —H, alkyls, aminos, alkylaminos, arylaminos, cycloalkylaminos, heterocyclylaminos, halogens, alkoxys, and hydroxys;

each R 3 is individually selected from the group consisting of —H, alkyls, alkylaminos, arylaminos, cycloalkylaminos, heterocyclylaminos, alkoxys, hydroxys, cyanos, halogens, perfluoroalkyls, alkylsulfinyls, alkylsulfonyls, R 4 NHSO 2 —, and —NHSO 2 R 4 ;

each R 5 is individually selected from the group consisting of —H, alkyls, aryls, heterocyclyls, alkylaminos, arylaminos, cycloalkylaminos, heterocyclylaminos, hydroxys, alkoxys, aryloxys, alkylthios, arylthios, cyanos, halogens, perfluoroalkyls, alkylcarbonyls, and nitros; and each W is individually selected from the group consisting of CH and N;

each X is individually selected from the group consisting of —O—, —S—, —NR 6 —, —NR 6 SO 2 —, —NR 6 CO—, alkynyls, alkenyls, alkylenes, —O(CH 2 ) h —, and —NR 6 (CH 2 ) h —, where each h is individually selected from the group consisting of 1, 2, 3, or 4, and where for each of alkylenes, —O(CH 2 ) h —, and —NR 6 (CH 2 ) h —, one of the methylene groups present therein may be optionally double-bonded to a side-chain oxo group except that where —O(CH 2 ) h —the introduction of the side-chain oxo group does not form an ester moiety;

A is selected from the group consisting of phenyl, naphthyl, pyridyl, pyrimidyl, thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, indolyl, indazolyl, benzimidazolyl, benzotriazolyl, isoquinolyl, quinolyl, benzothiazolyl, benzofuranyl, benzothienyl, pyrazolylpyrimidinyl, imidazopyrimidinyl, purinyl, and

where each W 1 is individually selected from the group consisting of —CH— and —N—;

D is phenyl or a five-membered heterocyclic ring selected from the group consisting of pyrazolyl, pyrrolyl, imidazolyl, oxazolyl, and thiazolyl;

G is —CH 2 —;

L is —C(O)—;

j is 0 or 1;

m is 0 or 1;

n is 0 or 1;

Q is

each R 4 group is individually selected from the group consisting of —H, alkyls, aminoalkyls, alkoxyalkyls, aryls, aralkyls, heterocyclyls, and heterocyclylalkyls except when the R 4 substituent places a heteroatom on an alpha-carbon directly attached to a ring nitrogen on Q;

when two R 4 groups are bonded with the same atom, the two R 4 groups optionally form an alicyclic or heterocyclic 4-7 membered ring;

each R 6 is individually selected from the group consisting of —H, alkyls, allyls, and β-trimethylsilylethyl;

each Z is individually selected from the group consisting of —O— and —N(R 4 )—;

each ring of formula (I) optionally includes one or more of R 7 , where R 7 is a noninterfering substituent individually selected from the group consisting of —H, alkyls, aryls, heterocyclyls, alkylaminos, arylaminos, cycloalkylaminos, heterocyclylaminos, hydroxys, alkoxys, aryloxys, alkylthios, arthylthios, cyanos, halogens, nitrilos, nitros, alkylsulfinyls, alkylsulfonyls, aminosulfonyls, and perfluoroalkyls.

2. The method of claim 1 , wherein m is 0; wherein D is substituted by a first R 7 substituent.

3. The method of claim 2 , wherein A is phenyl substituted by one or more second R 7 , substituents, said second R 7 substituents being halogens.

4. The method of claim 2 , wherein A is an R 7 -substituted naphthyl.

5. The method of claim 1 , wherein m is 1; R 1 is taken from the group consisting of

6. The method of claim 5 , wherein A is taken from phenyl or naphthyl.

7. The method of claim 1 , said molecule having the formula IB

8. The method of claim 1 , said molecule having the formula IC