Prodrugs of 2,4-pyrimidinediamine compounds and their uses
View Patent ↗The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds of structural formula shown below, compositions comprising these compounds, intermediates and methods for synthesizing these compounds, and methods for using these compounds in a variety of applications including treatment of autoimmune diseases.
1. A compound according to structural formula (IIIa):
or a pharmaceutically acceptable salt wherein R p is —CH 2 —O—P(O)(OH) 2 .
2. The compound of claim 1 which is a pharmaceutically acceptable salt.
3. The compound of claim 2 which is an alkali metal salt.
4. The compound of claim 3 which is a sodium salt.
5. The compound of claim 4 which is a disodium salt.
6. The compound of claim 3 which is a potassium salt.
7. The compound of claim 6 which is a dipotassium salt.
8. The compound of claim 2 which is an alkaline earth metal salt.
9. The compound of claim 8 which is a calcium salt.
10. The compound of claim 8 which is a magnesium salt.
11. The compound of claim 2 which is an alkylamino salt.
12. The compound of claim 2 which is an ammonium salt.
13. N4-(2,2-dimethyl-4-[(dihydrogen phosphonoxy)methyl]-3-oxo-5-pyrido [1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine disodium salt hexahydrate.