Solubilizing agents for active or functional organic compounds
View Patent ↗An active or functional organic compound is solubilized by an ester of an aryl alcohol, e.g., phenethyl, benzyl or substituted benzyl alcohol, and an alkyl or cycloalkyl carboxylic acid, or by a carbonate of said aryl alcohol and an alkyl or cycloalkyl carbonic acid.
1. A composition of an active or functional organic compound solubilized in 2-phenylethyl cyclopropanoate.
2. A composition according to claim 1 in which said active compound is a solid organic compound.
3. A composition according to claim 1 wherein said active or functional compound is a personal care, cosmetic, or pharmaceutical compound.
4. A composition according to claim 1 which is a sunscreen composition.
5. A sunscreen composition according to claim 4 in which said active compound is solubilized in an amount of at least 10 wt. %.
6. A sunscreen composition according to claim 4 in which said active is avobenzone, oxybenzone, 4-methylbenzylidene camphor, ethylhexyl triazone or bis-thylhexyloxyphenol methoxyphenyl triazine, or mixtures thereof.
7. A sunscreen composition according to claim 5 in which said active is avobenzone, oxybenzone, 4-methylbenzylidene camphor, ethylhexyl triazone or bis-ethylhexyloxyphenol methoxyphenyl triazine, or mixtures thereof.
8. A sunscreen composition according to claim 4 in which said active is selected from the group consisting of avobenzone, benzophenone-3, benzophenone-4, benzophenone-5, 4-methylbenzylidene camphor, p-aminobenzoic acid (PABA), camphor benzalkonium methosulfate, homosalate, phenylbenzimidazole sulfonic acid, terephthalidene dicamphor sulfonic acid, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25 PABA, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 3-benzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl PABA, methylene bis-benztriazolyl tetramethylbutylphenol, disodium phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, and mixtures thereof.
9. A sunscreen composition according to claim 5 in which said active is selected from the group consisting of avobenzone, benzophenone-3, benzophenone-4, benzophenone-5, 4-methylbenzylidene camphor, p-aminobenzoic acid (PABA), camphor benzalkonium methosulfate, homosalate, phenylbenzimidazole sulfonic acid, terephthalidene dicamphor sulfonic acid, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25 PABA, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 3-benzylidene camphor; ethylhexyl salicylate; ethylhexyl-dimethyl PABA; methylene bis-benztriazolyl tetramethylbutylphenol, disodium phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, and mixtures thereof.
10. A composition according to claim 1 wherein said active or functional organic compound is selected from the group consisting of agricultural and industrial compounds.
11. A composition according to claim 1 wherein said active or functional organic compound is selected from the group consisting of furosemide, lovastatin, clarithromycin, diclofenac, famotidine, carbamaxepine, dipyridamole, chlorthiazide, spironolactone, dilantin, imipranine, melfloquine, cyclosporine, glyburide, nimodipine, and mixtures thereof.
12. A composition according to claim 1 comprising a UV filter compound and a pharmaceutical compound.
13. A composition according to claim 1 comprising at least two active or functional organic compounds selected from the group consisting of UV filter, cosmetic, and pharmaceutical compounds.
14. A composition according to claim 12 comprising a UV filter compound selected from the group consisting of avobenzone, benzophenone-3, benzophenone-4, benzophenone-5, 4-methylbenzylidene camphor, p-aminobenzoic acid (PABA), camphor benzalkonium methosulfate, homosalate, phenylbenzimidazole sulfonic acid, terephthalidene dicamphor sulfonic acid, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25 PABA, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 3-benzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl PABA, methylene bis-benztriazolyl tetramethylbutylphenol, disodium phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, and mixtures thereof, and a pharmaceutical compound selected from the group consisting of furosemide, lovastatin, clarithromycin, diclofenac, famotidine, carbamaxepine, dipyridamole, chlorthiazide, spironolactone, dilantin, imipranine, melfloquine, cyclosporine, glyburide, nimodipine, and mixtures thereof.