Medical device with antimicrobial layer
A medical device includes a conduit for a fluid. The conduit has a wall formed of a hydrophobic polymer with a hydrophilic polymer layer extruded over it, and an antimicrobial substantially dispersed within the hydrophilic polymer. The antimicrobial compound may be a predetermined amount of phosphorus-based glass having a predetermined quantity of a metal such as silver substantially dispersed therein. The medical device may be an endotracheal tube made by providing a hydrophobic polymer, a hydrophilic polymer and an antimicrobial compound, forming the hydrophobic polymer, the hydrophilic polymer and the antimicrobial compound into a conduit, and forming a cuff on an end of the conduit.
1 . A method of making a medical device wall, the method comprising:
providing a hydrophobic polymer;
extruding the hydrophobic polymer to form a medical device wall;
providing an antimicrobial compound comprising a predetermined amount of water-soluble glass having a predetermined quantity of metal substantially dispersed therein;
mixing the antimicrobial compound and a hydrophilic polymer; and
extruding a layer of the hydrophilic polymer having the antimicrobial compound substantially dispersed therein over at least a portion of a surface of the wall.
2 . The method, as set forth in claim 1 , wherein the metal comprises copper, gold, silver, zinc, magnesium, boron, iodine, manganese, selenium, chromium, allium or a combination thereof.
3 . The method, as set forth in claim 1 , wherein the metal comprises substantially elemental metal, metal ions, metal oxide or a combination thereof.
4 . The method, as set forth in claim 1 , wherein the hydrophobic polymer comprises a conduit.
5 . The method, as set forth in claim 4 , wherein the layer is extruded onto an inner surface of the conduit, an outer surface of the conduit, or both.
6 . The method, as set forth in claim 4 , comprising:
providing a cuff on an end of the conduit.
7 . The method, as set forth in claim 6 , wherein the layer is extruded onto at least a portion of the cuff or the conduit.
8 . The method, as set forth in claim 1 , wherein the antimicrobial compound and the hydrophobic polymer are co-extruded.
9 . The method, as set forth in claim 1 , wherein the layer is between 0.002 mm-2.5 mm in thickness.
10 . The method, as set forth in claim 1 , wherein the hydrophilic polymer comprises polyurethane.
11 . The method, as set forth in claim 1 , wherein the hydrophilic polymer comprises medical grade hydrophilic thermoplastic polyurethane.
12 . The method, as set forth in claim 1 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of up to about 0.01 μ-grams/cm 2 /day.
13 . The method, as set forth in claim 1 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of between about 0.01 and about 1.0 μ-grams/cm 2 /day.
14 . The method, as set forth in claim 1 , wherein the metal is adapted to be released from the phosphorous-based at an elution rate of about 0.4 μ-grams/cm 2 /day.
15 . The method, as set forth in claim 1 , wherein the water-soluble glass comprises about 0.1-50% by weight of the antimicrobial compound.
16 . The method, as set forth in claim 1 , wherein the hydrophobic polymer comprises polyvinyl chloride, polyethylene, polyurethane, polydimethylsiloxane, polyester, silicone, or rubber.
17 . The method, as set forth in claim 1 , comprising forming an endotracheal tube comprising the medical device wall.
18 . The method, as set forth in claim 1 , comprising mixing the antimicrobial compound and a hydrophilic polymer with an indicator of carbon dioxide concentration, a bronchodilator, an anti-inflammatory agent, or a local anesthetic.
19 . A method comprising:
providing a medical device comprising a hydrophobic polymer;
providing a mixture comprising a hydrophilic polymer and a water-soluble glass, wherein the water-soluble glass has a quantity of metal substantially dispersed therein; and
extruding a layer of the mixture over at least a portion of the hydrophobic polymer.
20 . The method, as set forth in claim 19 , wherein the metal comprises copper, gold, silver, zinc, magnesium, boron, iodine, manganese, selenium, chromium, allium or a combination thereof.
21 . The method, as set forth in claim 19 , wherein the metal comprises substantially elemental metal, metal ions, metal oxide or a combination thereof.
22 . The method, as set forth in claim 19 , wherein the hydrophobic polymer comprises a conduit.
23 . The method, as set forth in claim 22 , wherein the mixture is extruded onto an inner surface of the conduit, an outer surface of the conduit, or both.
24 . The method, as set forth in claim 22 , comprising:
providing a cuff on an end of the conduit.
25 . The method, as set forth in claim 24 , wherein the mixture is extruded onto at least a portion of the cuff or the conduit.
26 . The method, as set forth in claim 19 , wherein the mixture and the hydrophobic polymer are co-extruded.
27 . The method, as set forth in claim 19 , wherein the layer is between 0.002 mm-2.5 mm in thickness.
28 . The method, as set forth in claim 19 , wherein the water-soluble glass comprises a phosphorous-based glass.
29 . The method, as set forth in claim 19 , wherein the hydrophilic polymer comprises polyurethane.
30 . The method, as set forth in claim 19 , wherein the hydrophilic polymer comprises medical grade hydrophilic thermoplastic polyurethane.
31 . The method, as set forth in claim 19 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of up to about 0.01 μ-grams/cm 2 /day.
32 . The method, as set forth in claim 19 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of between about 0.01 and about 1.0 μ-grams/cm 2 /day.
33 . The method, as set forth in claim 19 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of about 0.4 μ-grams/cm 2 /day.
34 . The method, as set forth in claim 19 , wherein the water-soluble glass comprises about 0.1-50% by weight of the mixture.
35 . The method, as set forth in claim 19 , wherein the hydrophobic polymer comprises polyvinyl chloride, polyethylene, polyurethane, polydimethylsiloxane, polyester, silicone, or rubber.
36 . The method, as set forth in claim 19 , wherein the medical device comprises an endotracheal tube.
37 . The method, as set forth in claim 19 , wherein the mixture comprises an indicator of carbon dioxide concentration, a bronchodilator, an anti-inflammatory agent, or a local anesthetic.
38 . A medical device comprising:
a hydrophobic polymer substrate, and
an extrusion covering at least a portion of the hydrophobic polymer substrate, the extrusion comprising a hydrophilic polymer and a water-soluble glass, wherein the water-soluble glass has a quantity of metal substantially dispersed therein.
39 . The medical device, as set forth in claim 38 , wherein the metal comprises copper, gold, silver, zinc, magnesium, boron, iodine, manganese, selenium, chromium, allium or a combination thereof.
40 . The medical device, as set forth in claim 38 , wherein the metal comprises substantially elemental metal, metal ions, metal oxide or a combination thereof.
41 . The medical device, as set forth in claim 38 , wherein the hydrophobic polymer comprises a conduit.
42 . The medical device, as set forth in claim 41 , wherein the extrusion is disposed on an inner surface of the conduit, an outer surface of the conduit, or both.
43 . The medical device, as set forth in claim 41 , wherein the conduit comprises a cuff.
44 . The medical device, as set forth in claim 43 , wherein the extrusion is disposed on at least a portion of the cuff.
45 . The medical device, as set forth in claim 38 , comprising a co-extruded hydrophobic polymer.
46 . The medical device, as set forth in claim 38 , wherein the extrusion is between 0.002 mm-2.5 mm in thickness.
47 . The medical device, as set forth in claim 38 , wherein the water-soluble glass comprises a phosphorous-based glass.
48 . The medical device, as set forth in claim 38 , wherein the hydrophilic polymer comprises polyurethane.
49 . The medical device, as set forth in claim 38 , wherein the hydrophilic polymer comprises medical grade hydrophilic thermoplastic polyurethane.
50 . The medical device, as set forth in claim 38 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of up to about 0.01 μ-grams/cm 2 /day.
51 . The medical device, as set forth in claim 38 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of between about 0.01 and about 1.0 μ-grams/cm 2 /day.
38 . The medical device, as set forth in claim 38 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of about 0.4 μ-grams/cm 2 /day.
53 . The medical device, as set forth in claim 38 , wherein the water-soluble glass comprises about 0.1-50% by weight of the mixture.
54 . The medical device, as set forth in claim 38 , wherein the hydrophobic polymer comprises polyvinyl chloride, polyethylene, polyurethane, polydimethylsiloxane, polyester, silicone, or rubber.
55 . The medical device, as set forth in claim 38 , wherein the medical device comprises an endotracheal tube.
56 . The medical device, as set forth in claim 38 , wherein the extrusion comprises an indicator of carbon dioxide concentration, a bronchodilator, an anti-inflammatory agent, or a local anesthetic.
57 . The medical device, as set forth in claim 38 , comprising a ventilation device operatively connected to the medical device.
58 . A medical device comprising:
a device wall, wherein at least a portion of the device wall is an extrusion, the extrusion being formed from a mixture comprising a hydrophobic polymer substrate, a hydrophilic polymer and a water-soluble glass, wherein the water-soluble glass has a quantity of metal substantially dispersed therein.
59 . The medical device, as set forth in claim 58 , wherein the metal comprises copper, gold, silver, zinc, magnesium, boron, iodine, manganese, selenium, chromium, allium or a combination thereof.
60 . The medical device, as set forth in claim 58 , wherein the metal comprises substantially elemental metal, metal ions, metal oxide or a combination thereof.
61 . The medical device, as set forth in claim 58 , wherein the medical device comprises a conduit.
62 . The medical device, as set forth in claim 58 , wherein the conduit comprises a cuff.
63 . The medical device, as set forth in claim 58 , wherein the water-soluble glass comprises a phosphorous-based glass.
64 . The medical device, as set forth in claim 58 , wherein the hydrophilic polymer comprises polyurethane.
65 . The medical device, as set forth in claim 58 , wherein the hydrophilic polymer comprises medical grade hydrophilic thermoplastic polyurethane.
66 . The medical device, as set forth in claim 58 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of up to about 0.01 μ-grams/cm 2 /day.
67 . The medical device, as set forth in claim 58 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of between about 0.01 and about 1.0 μ-grams/cm 2 /day.
68 . The medical device, as set forth in claim 58 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of about 0.4 μ-grams/cm 2 /day.
69 . The medical device, as set forth in claim 58 , wherein the water-soluble glass comprises about 0.1-50% by weight of the compounded mixture.
70 . The medical device, as set forth in claim 58 , wherein the hydrophobic polymer comprises polyvinyl chloride, polyethylene, polyurethane, polydimethylsiloxane, polyester, silicone, or rubber.
71 . The medical device, as set forth in claim 58 , wherein the medical device comprises an endotracheal tube.
72 . The medical device, as set forth in claim 58 , wherein the medical device comprises an indicator of carbon dioxide concentration, a bronchodilator, an anti-inflammatory agent, or a local anesthetic.
73 . The medical device, as set forth in claim 58 , comprising a ventilation device operatively connected to the medical device.
74 . An endotracheal cuff comprising:
a hydrophobic polymer substrate, and
an extrusion covering at least a portion of the hydrophobic polymer substrate, the extrusion comprising a hydrophilic polymer and a water-soluble glass, wherein the water-soluble glass has a quantity of metal substantially dispersed therein.
75 . The endotracheal cuff, as set forth in claim 74 wherein the metal comprises copper, gold, silver, zinc, magnesium, boron, iodine, manganese, selenium, chromium, allium or a combination thereof.
76 . The endotracheal cuff, as set forth in claim 74 , wherein the metal comprises substantially elemental metal, metal ions, metal oxide or a combination thereof.
77 . The endotracheal cuff, as set forth in claim 74 , comprising a conduit.
78 . The endotracheal cuff, as set forth in claim 74 , comprising a co-extruded hydrophobic polymer.
79 . The endotracheal cuff, as set forth in claim 74 , wherein the extrusion is between 0.002 mm-2.5 mm in thickness.
80 . The endotracheal cuff, as set forth in claim 74 , wherein the water-soluble glass comprises a phosphorous-based glass.
81 . The endotracheal cuff, as set forth in claim 74 , wherein the hydrophilic polymer comprises polyurethane.
82 . The endotracheal cuff, as set forth in claim 74 , wherein the hydrophilic polymer comprises medical grade hydrophilic thermoplastic polyurethane.
83 . The endotracheal cuff, as set forth in claim 74 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of up to about 0.01 μ-grams/cm 2 /day.
84 . The endotracheal cuff, as set forth in claim 74 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of between about 0.01 and about 1.0 μ-grams/cm 2 /day.
85 . The endotracheal cuff, as set forth in claim 74 , wherein the metal is adapted to be released from the water-soluble glass at an elution rate of about 0.4 μ-grams/cm 2 /day.
86 . The endotracheal cuff, as set forth in claim 74 , wherein the water-soluble glass comprises about 0.1-50% by weight of the mixture.
87 . The endotracheal cuff, as set forth in claim 74 , wherein the hydrophobic polymer comprises polyvinyl chloride, polyethylene, polyurethane, polydimethylsiloxane, polyester, silicone, or rubber.
88 . The endotracheal cuff, as set forth in claim 74 , comprising an endotracheal tube.
89 . The endotracheal cuff, as set forth in claim 74 , wherein the extrusion comprises an indicator of carbon dioxide concentration, a bronchodilator, an anti-inflammatory agent, or a local anesthetic.
90 . The endotracheal cuff, as set forth in claim 74 , comprising a ventilation device operatively connected to the endotracheal cuff by a conduit.