Sulfacetamide formulations for treatment of skin dermatoses
A topical composition for the treatment of mammalian skin dermatoses comprising a sulfacetamide or a derivative thereof and at least 1 sunscreen wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 1.6 to about 20.6. Also provided is a method of treating mammalian dermatoses by administering a topical composition comprising a sulfacetamide or a derivative thereof and at least 1 sunscreen wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 1.6 to about 20.6.
1. A topical composition for the treatment of mammalian skin dermatoses comprising at least one sulfacetamide or a salt thereof, sulfur and at least one sunscreen, wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 1.6 to about 20.6 and is selected from the group consisting of p-aminobenzoic acid, avobenzone, cinozate, dioxybenzone, ensulizole, homosalate, methyl anthranilate, octocrylene, octyl dimethyl PABA, octyl methoxycinnamate, octyl salicylate, oxybenzone, sulisobenzone, trolamine salicylate, 3-benzylidene camphor, benzylidene camphor sulfonic acid, bisymidazylate, camphor benzalkonium methosulfate, diethylamino hydroxybenzoyl hexyl benzoate, diethylhexyl butamido triazone, diemethicodiethylbenzal malonate, drometrizole trisiloxane, ecamsule, isoamyl p-methoxycinnamate, 4-methylbenzylidene camphor, octyl triazone, PEG 25-PABA, polyacrylamidomethyl benzylidene camphor, sulisobenzone, tinosorb M, tinosorb S and mixtures thereof.
2. The composition of claim 1 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 8 to about 20.
3. The composition of claim 1 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 8 to about 15.
4. The composition of claim 1 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 15 to about 20.
5. The composition of claim 1 wherein the dermatoses is selected from the group consisting of topical bacterial infections, rosacea, impetigo, folliculitis, erythasma, and combinations thereof.
6. The composition of claim 1 wherein the dermatoses is selected from the group consisting of gram positive bacteria, gram negative bacteria, and a combination thereof.
7. The composition of claim 1 wherein the dermatoses is selected from the group consisting of antimicrobial resistant bacterial infections, atopic dermatitis, bromhidrosis, chronic paronychia, desquamative inflammatory vaginitis, Fox Fordyce Disease, Hailey-Hailey Disease, Hidradenitits suppurativa, intertrigo, nummular dermatitis, otopyorrhea, perioral dermatitis, angular chelitis, psoriasis, seborrheic dermatitis, skin ulcers, and combinations thereof.
8. A method of treating mammalian dermatoses by administering a topical composition comprising at least one sulfacetamide or a salt thereof, sulfur and at least one sunscreen, wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 1.6 to about 20.6 and is selected from the group consisting of p-aminobenzoic acid, avobenzone, cinozate, dioxybenzone, ensulizole, homosalate, methyl anthranilate, octocrylene, octyl dimethyl PABA, octyl methoxycinnamate, octyl salicylate, oxybenzone, sulisobenzone, trolamine salicylate, 3-benzylidene camphor, benzylidene camphor sulfonic acid, bisymidazylate, camphor benzalkonium methosulfate, diethylamino hydroxybenzoyl hexyl benzoate, diethylhexyl butamido triazone, diemethicodiethylbenzal malonate, drometrizole trisiloxane, ecamsule, isoamyl p-methoxycinnamate, 4-methylbenzylidene camphor, octyl triazone, PEG 25-PABA, polyacrylamidomethyl benzylidene camphor, sulisobenzone, tinosorb M, tinosorb S and mixtures thereof.
9. The method of claim 8 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 8 to about 20.
10. The method of claim 8 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 8 to about 15.
11. The method of claim 8 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 15 to about 20.
12. The method of claim 8 wherein the dermatoses is selected from the group consisting of topical bacterial infections, rosacea, impetigo, folliculitis, erythasma, and combinations thereof.
13. The method of claim 8 wherein the dermatoses is selected from the group consisting of gram positive bacteria, gram negative bacteria, and a combination thereof.
14. The method of claim 8 wherein the dermatoses is selected from the group consisting of antimicrobial resistant bacterial infections, atopic dermatitis bromhidrosis, chronic paronychia, desquamative inflammatory vaginitis, Fox Fordyce Disease, Hailey-Hailey Disease, Hidradenitits suppurativa, intertrigo, nummular dermatitis, otopyorrhea, perioral dermatitis, angular chelitis, psoriasis, seborrheic dermatitis, skin ulcers, and combinations thereof.
15. A topical composition for the treatment of mammalian skin dermatoses comprising sulfacetamide, sulfur and at least one sunscreen, wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 1.6 to about 20.6, the sunscreen is selected from the group consisting of p-aminobenzoic acid, avobenzone, cinozate, dioxybenzone, ensulizole, homosalate, methyl anthranilate, octocrylene, octyl dimethyl PABA, octyl methoxycinnamate, octyl salicylate, oxybenzone, sulisobenzone, trolamine salicylate, 3-benzylidene camphor, benzylidene camphor sulfonic acid, bisymidazylate, camphor benzalkonium methosulfate, diethylamino hydroxybenzoyl hexyl benzoate, diethylhexyl butamido triazone, diemethicodiethylbenzal malonate, drometrizole trisiloxane, ecamsule, isoamyl p-methoxycinnamate, 4-methylbenzylidene camphor, octyl triazone, PEG 25-PABA, polyacrylamidomethyl benzylidene camphor, sulisobenzone, tinosorb M, tinosorb S and mixtures thereof, and wherein the composition exhibits less than 10% decomposition of sulfacetamide or sunscreen after storage at 2500 for 180 days.
16. The composition of claim 15 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 8 to about 20.
17. The composition of claim 15 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 8 to about 15.
18. The composition of claim 15 , wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 15 to about 20.
19. The composition of claim 15 wherein the dermatoses is selected from the group consisting of topical bacterial infections, rosacea, impetigo, folliculitis, erythasma, and combinations thereof.
20. The composition of claim 15 wherein the dermatoses is selected from the group consisting of gram positive bacteria, gram negative bacteria, and a combination thereof.
21. The composition of claim 15 wherein the dermatoses is selected from the group consisting of antimicrobial resistant bacterial infections, atopic dermatitis, bromhidrosis, chronic paronychia, desquamative inflammatory vaginitis, Fox Fordyce Disease, Hailey-Hailey Disease, Hidradenitits suppurativa, intertrigo, nummular dermatitis, otopyorrhea, perioral dermatitis, angular chelitis, psoriasis, seborrheic dermatitis, skin ulcers, and combinations thereof.