IP Library › Patent Application 11343714
Patent Application
App. No. 11/343,714

Compositions and methods for coating medical implants

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
11/343,714
Abstract

Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.

Claims (18)

1 . A medical implant, comprising a suture or a thread and an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, or platinum complex.

2 . The medical implant of claim 1 wherein the implant is covered or coated in whole or in part with a composition comprising an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, or platinum complex.

3 . The medical implant of claim 1 or 2 wherein the anthracycline is doxorubicin or mitoxantrone.

4 . The medical implant of claim 1 or 2 wherein the fluoropyrimidine is 5-fluorouracil.

5 . The medical implant of claim 1 or 2 wherein the folic acid antagonist is methotrexate.

6 . The medical implant of claim 1 or 2 wherein the podophylotoxin is etoposide.

7 . The medical implant of claim 2 wherein the composition further comprises a polymer.

8 . The medical implant of claim 7 wherein the polymer is a biodegradable polymer.

9 . The medical implant of claim 7 wherein the polymer is a non-biodegradable polymer.

10 . The medical implant of claim 7 wherein the polymer is a polyurethane.

11 . The medical implant of claim 7 wherein the polymer is a poly(lactide-co-glycolide).

12 . The medical implant of any one of claims 7 to 11 wherein the fluoropyrimidine is 5-fluorouracil.

13 . The medical implant of claim 1 wherein the implant releases the anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, or platinum complex.

14 . A method for reducing or inhibiting infection associated with a medical implant, comprising the step of introducing into a patient the medical implant of claim 1 .

15 . The method of claim 14 wherein the fluoropyrimidine is 5-fluorouracil.

16 . A method for making a medical implant, comprising covering or coating a suture or a thread with an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, or platinum complex.

17 . The method of claim 16 wherein the fluoropyrimidine is 5-fluorouracil.

18 . The method of claim 16 wherein the suture or the thread is covered or coated by dipping or by impregnation.