Methods for treating restenosis with a
View Patent ↗The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease.
1. A method for treating restenosis in a patient, the method comprising the steps of: (a) administering an effective amount of a botulinum neurotoxin directly into the wall of the patient's blood vessel in the area of the restenosis prior to performing an angioplasty procedure; and (b) performing the angioplasty procedure, thereby treating restenosis in the patient.
2. The method of claim 1 , wherein the administering of the botulinum neurotoxin is effective in reducing or eliminating restenosis following an angioplasty procedure.
3. The method of claim 1 , wherein the angioplasty does not include the step of inserting a stent into the blood vessel.
4. The method of claim 1 , wherein the administering of the botulinum neurotoxin reduces or eliminates damage to a blood vessel.
5. The method of claim 1 , wherein the administering of the botulinum is effective in dilating the blood vessel.
6. The method of claim 1 , wherein the administering of the botulinum is effective in reducing or eliminating inflammation the blood vessel.
7. The method of claim 1 , wherein the botulinum neurotoxin is selected from the group consisting of botulinum neurotoxin types A, B, C, D, E, F, G, and combinations thereof.
8. The method of claim 1 , wherein the botulinum neurotoxin is botulinum neurotoxin type A.
9. The method of claim 1 , further comprising inserting a stent, having botulinum neurotoxin coated or impregnated thereon, into the blood vessel after administering the botulinum neurotoxin.
10. A method for treating restenosis in a patient, the method comprising the step of administering an effective amount of a botulinum neurotoxin type A to a blood vessel of the patient having restenosis prior to performing an angioplasty procedure; and performing the angioplasty procedure, thereby treating the restenosis in the patient.
11. The method of claim 10 , wherein the botulinum neurotoxin type A is administered to a blood vessel wall at or near the restenosis.
12. The method of claim 10 , wherein the administering comprises injecting the botulinum neurotoxin type A into a blood vessel wall.
13. The method of claim 10 , further comprising inserting a botulinum neurotoxin type A coated or impregnated stent at or near the restenosis.
14. The method of claim 10 , further comprising inserting a stent at or near the restenosis.