Method of treatment body tissue using a non-uniform laser beam
View Patent ↗Methods and apparatus for treatment, such as skin rejuvenation treatment, using non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:YAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a non-uniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the target tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production). A large area of tissue, preferably 7-10 mm in diameter, can be treated simultaneously, while minimizing the risk of burning or other damage to the skin. In one embodiment, the invention uses a fiber bundle to provide a non-uniform energy output beam. In another embodiment, the invention uses a diffractive lens array to produce the non-uniform output beam. A cooling system can also be integrated with the laser treatment system.
1. A method of treating human tissue, comprising:
generating an output beam from a laser source; coupling the beam into an optical system that modifies the beam to provide a treatment beam having a non-uniform energy profile, said non-uniform energy profile being comprised of regions of relatively high energy per unit area within a substantially uniform background region of relatively low energy per unit area in comparison to the regions of relatively high energy per unit area; and
directing the treatment beam to a target tissue area such that the regions of relatively high energy per unit area deliver sufficient energy to target tissue to beat select portions of the target tissue to a first temperature to shrink collagen and wherein the substantially uniform background region of relatively low energy per unit area delivers sufficient energy to target tissue to stimulate collagen production in the remaining portion of the target tissue.
2. The method of claim 1 , wherein the treatment beam at the regions of relatively high energy per unit area heats select portions of the target tissue to a temperature of 70°C. or higher.
3. The method of claim 1 , wherein the laser source comprises an Nd:YAG laser.
4. The method of claim 1 , wherein the wavelength of the output beam is between about 1.3 microns and 1.6 microns.
5. The method of claim 1 , wherein the wavelength of the output beam is between about 1.40 and 1.44 microns.
6. The method of claim 1 , wherein the treatment beam at the target tissue area has a diameter between about 7 and 10 mm., and wherein the average fluence of the treatment beam at the target tissue area is less than about 10 J/cm 2 .
7. The method of claim 1 , wherein the output beam has a pulse duration of between 0.1 and 100 milliseconds.
8. The method of claim 7 , wherein the output beam has a pulse duration of between 1 and 5 milliseconds.
9. The method of claim 1 , wherein the optical system comprises a fiber bundle.
10. The method of claim 9 , wherein the fiber bundle comprises between about 1000 and about 2000 fibers.
11. The method of claim 10 , wherein the optical system comprises focusing lens for coupling the output beam into a proximal end of the fiber bundle, and an optical window between the distal end of the fiber bundle and the target tissue, the optical window permitting the beam emitted from each fiber in the bundle to diverge before it reaches the target skin so that each beam partially overlaps with the beam(s) from adjacent fibers in the bundle.
12. The method of claim 11 , wherein the optical window is between 1 and 5 mm thick.
13. The method of claim 1 , wherein the optical system comprises a diffractive lens array arranged in an optical path between a laser source and the treatment area, such that each lens in the array provides a high-intensity zone surrounded by a low intensity zone of radiation.
14. The method of claim 13 , wherein the diffractive lens array comprises between about 100 and about 2000 lenses in the array.
15. The method of claim 14 , wherein each lens is between about 150 and 1000 microns in diameter.
16. The method of claim 13 , wherein the diffractive lens array is between 7 and 10 millimeters in diameter.
17. The method of claim 1 , wherein the ratio of peak energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 4.5 to 1.
18. The method of claim 1 , wherein the ratio of the average energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 10 to 1.
19. The method of claim 1 , wherein the ratio of average energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 50 to 1.
20. The method of claim 1 , wherein the ratio of average energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 100 to 1.