Mutagenic nucleoside analogs for the treatment of viral disease
View Patent ↗The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides isoguanosine nucleosides and derivatives thereof as well a method of increasing the mutation rate of a virus such as bovine viral diarrhea virus (BVDV) and hepatitis C virus (HCV).
1. A method of increasing the mutation rate of a virus in a cell culture or in a subject in need thereof, comprising administering a compound to a virally infected cell in the cell culture or in the subject, wherein the compound has the structure:
wherein,
R 16 is a member selected from the group consisting of
in which,
R 6 and R 7 are independently selected from —OH, a monophosphate radical, and a triphosphate radical;
X and Y are independently selected from H and —OH, and with the proviso that one of X and Y is H and one of X and Y is OH; and
wherein
the virus is selected from the group consisting of hepatitis C virus and bovine viral diarrhea virus (BVDV).
2. The method according to claim 1 , wherein the cell is in cell culture.
3. The method according to claim 1 , wherein the cell is in an animal.
4. The method according to claim 1 , wherein the cell is a human cell.
5. The method according to claim 1 , wherein the virus is bovine viral diarrhea virus (BVDV).
6. The method according to claim 1 , wherein the virus is hepatitis C virus.