Nuclear factor κB inducing factor
View Patent ↗The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
1. An isolated nucleic acid encoding NFIF-7a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
2. The nucleic acid of claim 1 wherein said nucleic acid is a cDNA.
3. An expression vector comprising the isolated nucleic acid of claim 2 under the control of a promoter.
4. An isolated non-human host cell transformed or transfected with the expression vector of claim 3 .