Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment of prevention of gastric toxicity
View Patent ↗The invention provides hops ( Humulis lupulus ) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
1. A method of producing an analgesic and an anti-ulcerogenic effect in a mammal, comprising administering to the mammal an amount of a compound selected from the group consisting of dihydro-isohumulone, dihydro-isocohumulone, dihydro-isoadhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-isoadhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-isoadhumulone sufficient to produce an analgesic and anti-ulcerogenic effect in the mammal and a nonsteroidal anti-inflammatory compound selected from the group consisting of salicylic acid, methyl salicylate, difulunisal, salsalate, olsalazine, sulfasalazine, acetanilide, acetaminophen, phenacetin; mefenamic acid, sodium meclofenamate, tolmetin, ketorolac, diclofenac; ibuprofen, naproxen, sodium daproxen, fenoprofen, ketoprofen, flurbioprofen, oxaprozin, piroxicam, meloxicam, tenoxicam, ampiroxicam, droxicam, pivoxicam, phenylbutazone, oxyphenbutazone, anitpyrine, aminopyrine, dipyrone; celecoxib, rofecoxib; nabumetone; apazone; nimensulide; indomethacin; sulindac; and etodolac, whereby administration of said compound reduces gastric toxicity associated with said non-steroidal anti-inflammatory compound.
2. The method of claim 1 , wherein said compound is derived from hops.
3. The method of claim 1 , wherein the composition comprises about 0.5 to 10000 mg of said first compound.
4. The method of claim 3 , wherein the composition comprises about 50 to 7500 mg of the first compound.
5. The method of claim 1 , wherein the composition comprises about 0.001 to 10 weight percent of the first compound.
6. The method of claim 5 , wherein the composition comprises about 0.1 to 1 weight percent of the first compound.
7. The method of claim 1 , wherein the nonsteroidal anti-inflammatory compound is selected from the group consisting of salicylic acid, methyl salicylate, ibuprofen, naproxen, sodium daproxen, fenoprofen, ketoprofen, flurbioprofen, and oxaprozin.
8. The method of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.
9. The method of claim 1 , wherein the composition is administered orally, topically, parenterally, or rectally.
10. The method of claim 1 , wherein the compound is administered concomitantly with said non-steroidal anti-inflammatory compound.
11. The method of claim 1 , wherein said compound is administered after the administration of said non-steroidal anti-inflammatory compound.
12. The method of claim 1 , wherein said compound is administered before the administration of said non-steroidal anti-inflammatory compound.