IP Library › Granted Patent US 7,332,568
Granted Patent B2
US 7,332,568 · App. 11/356,829 · Granted Feb 19, 2008

Q3 SPARC deletion mutant and uses thereof

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Quick Facts
Patent No.
US 7,332,568
App. No.
11/356,829
Granted
Feb 19, 2008
Kind
B2
Abstract

The invention provides for SPARC polypeptides with a mutation corresponding to a deletion of the third glutamine in the mature form of the human SPARC protein, nucleic acids encoding such polypeptides, antibodies against such polypeptides, and methods of the use of such polypeptides, nucleic acids, and antibodies.

Claims (5)

1. An isolated secreted protein acidic and rich in cysteine (SPARC) polypeptide, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 2.

2. A composition comprising the polypeptide of claim 1 and a pharmaceutically acceptable carrier.

3. The composition of claim 2 , wherein the polypeptide is coupled to a therapeutic agent.

4. The composition of claim 3 , wherein the therapeutic agent is a radionuclide, drug, polypeptide or toxin.

5. The composition of claim 2 , wherein the polypeptide is coupled to a polyethylene glycol.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE ADDRESS OF THE ASSSIGNEE ABRAXIS BIOSCIENCE, INC., PREVIOUSLY RECORDED ON REEL 017706 FRAME 0682. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECT ADDRESS IS 11755 WILSHIRE BOULEVARD, SUITE 2000, LOS ANGELES, CALIFORNIA 90025. Recorded Jul 24, 2008
From: AMERICAN BIOSCIENCE, INC.
To: ABRAXIS BIOSCIENCE, INC.
Reel/Frame 021289/0820 →
MERGER Recorded Jun 2, 2006
From: AMERICAN BIOSCIENCE, INC.
To: ABRAXIS BIOSCIENCE, INC.
Reel/Frame 017706/0682 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2006
From: TRIEU, VUONG; DESAI, NEIL P.; SOON-SHIONG, PATRICK
To: AMERICAN BIOSCIENCE, INC.
Reel/Frame 017651/0990 →