Halosuccinimide biocide
The present invention relates to biocides. More particularly, the present invention relates to a novel solution that is an effective high level disinfectant biocide. The present invention biocide includes a halide substituted N-succinimide in an aqueous solution in the pH range of 2-6. The biocide also includes N-succinimide as a stabilizer. In some embodiments the biocide may further include an anti-corrosive agent.
1 . An aqueous biocide composition comprising
a) an N-halosuccinimide or derivative thereof;
b) a succinimide or a derivative thereof;
c) an anticorrosive agent; and
d) an aqueous carrier having a pH less than about 6.
2 . The biocide composition of claim 1 wherein the N-halosuccinimide is a compound of the formula:
where:
X is Cl, Br or I;
R1, R2, R3 and R4, alone or together are hydrogen, CH3-, CH3-(CH2)n-, or an aromatic ring; and
n is 1-8.
3 . The biocide composition of claim 2 wherein the N-halosuccinimide forms a compound of the formula:
where:
Y is C, SO or PO2;
the aromatic ring can be further substituted by R; and
R is a nitro, sulfo, or phospho group.
4 . The biocide composition of claim 1 wherein the N-halosuccinimide is a compound of the formula:
where:
X is Cl, Br or I; and
R1, R2, R3 and R4 are hydrogen.
5 . The biocide composition of claim 1 wherein the N-halosuccinimide is the N-chlorosuccinimide or the N-bromosuccinimide.
6 . The biocide composition of claim 1 wherein the N-halosuccinimide comprises 0.1 to 3% of the composition.
7 . The biocide composition of claim 1 wherein the succinimide or derivative thereof is a compound of the formula:
where:
X and R1-R4 are hydrogen, CH3-, CH3-(CH2)n-, or a substituted or unsubstituted aromatic ring; and
n is 1-8.
8 . The biocide composition of claim 1 wherein the succinimide or derivative thereof is succinimide.
9 . The biocide composition of claim 1 wherein the succinimide or derivative thereof comprises approximately 0.1-10% of the composition.
10 . The biocide composition of claim 1 wherein the anticorrosive agent is effective to inhibit metal corrosion.
11 . The biocide composition of claim 1 wherein the anticorrosive agent is selected from the group consisting of triazoles, alkylamines, and ethoxylates.
12 . The biocide composition of claim 1 wherein the anticorrosive agent comprises 0.01-1% of the composition.
13 . The biocide composition of claim 1 wherein the aqueous carrier has a pH in the range of about 2 to about 6.
14 . The biocide composition of claim 1 further comprising additional additives.
15 . The biocide composition of claim 1 further comprising one or more of the group consisting of surfactants, cosolvents, colorants, odorants, and buffers.
16 . The biocide composition of claim 1 further comprising a buffer.
17 . A method of sterilizing a surface comprising
a) contacting a surface with a biocide composition for a time sufficient to totally kill 10 6 microbial endospores, the composition including an N-halosuccinimide or derivative thereof, a succinimide or a derivative thereof, an anticorrosive agent, and an aqueous carrier having a pH less than about 6, and
b) rinsing the surface to remove residual biocide composition.
18 . The method of claim 17 wherein contacting the surface comprises contacting the surface of a medical device.
19 . The method of claim 17 wherein the contacting the surface comprises contacting the surface for about 30-600 seconds.
20 . The method of claim 17 wherein contacting the surface comprises contacting the surface for about 15-240 minutes.
21 . A method of stabilizing a N-halosuccinimide in an acidic aqueous composition comprising adding an effect amount of succinimide or derivative thereof to the aqueous composition.
22 . The method of claim 21 wherein the effective amount of succinimide or a derivative thereof in a range of 0.1-10% of the composition.
23 . The method of claim 1 wherein succinimide is added to the aqueous composition.
24 . A method of making an aqueous biocide composition comprising the steps of:
a) preparing an acetate buffer of approximately pH 3;
b) adding halosuccinimide whereby the halosuccinimide is about 1.5% of the composition;
c) adding succinimide to whereby the succinimide is about 9% of the composition; and
d) adding anti-corrosive agent whereby the anti-corrosive agent is about 0.5% of the concentration.