Antibiotic and combinations of antibiotic and symptomatic relief agent formulations
Disclosed herein are antibiotic formulations and combinations of antibiotic and symptomatic relief agent formulations. The combinations are suitable to treat a variety of diseases, including an infection, while treating the symptoms associated with the disease. Also disclosed are methods of treating a disease or an infection and its symptoms, as well as pharmaceutical kits containing such formulations.
1 .- 74 . (canceled)
75 . A dosage form, comprising
a therapeutically effective amount of trimethoprim; and
a therapeutically effective amount of sulfamethoxazole;
wherein trimethoprim is present in a first dosage form and sulfamethoxazole is present in a second dosage form, or
trimethoprim and sulfamethoxazole are present in a single dosage form containing both trimethoprim and sulfamethoxazole; and
wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:4, trimethoprim:sulfamethoxazole.
76 . (canceled)
77 . A pharmaceutical kit, comprising:
the dosage form of claim 75 , wherein
a plurality of the first and second dosage forms or a plurality of the single dosage forms are packaged in a container with instructions for a patient to carry out a dosing regimen for morning and evening dosing; and wherein the container optionally incorporates indicia for distinguishing between the first and the second dosage forms.
78 . The kit of claim 77 , wherein the dosage form is a tablet, capsule, sprinkle, candy, or liquid for oral administration.
79 . The kit of claim 77 , wherein the container comprises a plurality of compartments to retain the dosage forms, wherein the compartments are organized in a geometric orientation according to the dosing regimen.
80 . The kit of claim 79 , wherein the container is a blister pack, a blister card, a syringe, an eyedropper, or a combination comprising at least one of the foregoing containers.
81 . The kit of claim 77 , wherein the container comprises compartments organized for morning and evening dosing.
82 . The kit of claim 77 , wherein the trimethoprim is formulated in sustained-release form.
83 . The kit of claim 77 , wherein the first, second, or single dosage forms are packaged in dropper bottles, eyedroppers, syringes, ampules, or vials.
84 . The kit of claim 83 , wherein the dropper bottles, eyedroppers, syringes, ampules, or vials are pre-filled with the first, second, or single dosage forms.
85 . The kit of claim 77 , wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:3.
86 . The kit of claim 77 , wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:2.
87 .- 105 . (canceled)
106 . The dosage form of claim 75 , wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:3, trimethoprim:sulfamethoxazole.
107 . The dosage form of claim 75 , wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:2, trimethoprim: sulfamethoxazole.
108 . The dosage form of claim 75 , wherein the dosage form is a tablet, capsule, sprinlde, candy, or liquid for oral administration.
109 . The dosage form of claim 75 , wherein the trimethoprim is formulated in sustained-release form.
110 . The dosage form of claim 75 , wherein the dosage form is administered to a patient to treat or prevent an upper respiratory infection, bronchitis, pneumonia, sinusitis, urinary tract infection, or otitis media; or to treat opportunistic infection in an immunosuppressed patient.
111 . A method of treating or preventing an infection, comprising:
providing a dosage form to a patient, wherein the dosage form comprises
a therapeutically effective amount of trimethoprim; and
a therapeutically effective amount of sulfamethoxazole;
wherein trimethoprim is present in a first dosage form and sulfamethoxazole is present in a second dosage form, or
trimethoprim and sulfamethoxazole are present in a single dosage form containing both trimethoprim and sulfamethoxazole; and
wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:4, trimethoprim:sulfamethoxazole.
112 . The method of claim 111 , wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:3, trimethoprim:sulfamethoxazole.
113 . The method of claim 111 , wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:2, trimethoprim:sulfamethoxazole.
114 . The method of claim 111 , wherein the dosage form is administered to a patient to treat or prevent an upper respiratory infection, bronchitis, pneumonia, sinusitis, urinary tract infection, or otitis media; or to treat opportunistic infection in an imnuunosuppressed patient.
115 . A dosage form, comprising
a therapeutically effective amount of trimethoprim; and
a therapeutically effective amount of sulfamethoxazole;
wherein trimethoprim is present in a first dosage form and sulfamethoxazole is present in a second dosage form, or
trimethoprim and sulfamethoxazole are present in a single dosage form containing both trimethoprim and sulfamethoxazole; and
wherein the trimethoprim and sulfamethoxazole are present in a weight ratio of about 1:1 to about 1:2, trimethoprim:sulfamethoxazole.