Novel human membrane proteins and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
1 . An isolated nucleic acid molecule comprising a nucleotide sequence that encodes the amino acid sequence of SEQ ID NO:2, 4, 6, 9, 11, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 97, 99, 101, 103, 105, 107, 110, 112, 114, 116, 118, 120, 123, 125, 127, 129, 131, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 155, 158, 160, or 162.
2 . The isolated nucleic acid molecule of claim 1 , wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:1, 3, 5, 8, 10, 13, 15, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 96, 98, 100, 102, 104, 106, 109, 111, 113, 115, 117, 119, 122, 124, 126, 128, 130, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 154, 157, 159, or 161.
3 . An expression vector comprising the isolated nucleic acid molecule of claim 1 .
4 . An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2, 4, 6, 9, 11, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 97, 99, 101, 103, 105, 107, 110, 112, 114, 116, 118, 120, 123, 125, 127, 129, 131, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 155, 158, 160, or 162.
5 . The isolated polypeptide of claim 4 , comprising the amino acid sequence of SEQ ID NO: 97, 99, 101, 103, 105, 107, 110, 118, 120, 123, 125, 131, 134, 136, 138, 140, 142, 144, 146, 148, or 158.
6 . The isolated nucleic acid molecule of claim 1 , wherein said nucleic acid molecule encodes the amino acid sequence of SEQ ID NO: 97, 99, 101, 103, 105, 107, 110, 118, 120, 123, 125, 131, 134, 136, 138, 140, 142, 144, 146, 148, or 158.
7 . The isolated nucleic acid molecule of claim 1 , wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO: 96, 98, 100, 102, 104, 106, 117, 119, 122, 124, 130, 133, 135, 137, 139, 141, 143, 145, 147, or 157.
8 . An oligonucleotide that inhibits the expression of a nucleic acid molecule that encodes an amino acid sequence of SEQ ID NO: 2, 4, 6, 9, 11, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 97, 99, 101, 103, 105, 107, 110, 112, 114, 116, 118, 120, 123, 125, 127, 129, 131, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 155, 158, 160, or 162.
9 . The oligonucleotide of claim 8 , wherein said nucleic acid molecule encodes the amino acid sequence of SEQ ID NO: 97, 99, 101, 103, 105, 107, 110, 118, 120, 123, 125, 131, 134, 136, 138, 140, 142, 144, 146, 148, or 158.
10 . An antibody that selectively binds a polypeptide comprising an amino acid sequence of SEQ ID NOS: 2, 4, 6, 9, 11, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 97, 99, 101, 103, 105, 107, 110, 112, 114, 116, 118, 120, 123, 125, 127, 129, 131, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 155, 158, 160, or 162.
11 . The antibody claim 10 , wherein said polypeptide comprises the amino acid sequence of SEQ ID NO: 97, 99, 101, 103, 105, 107, 110, 118, 120, 123, 125, 131, 134, 136, 138, 140, 142, 144, 146, 148, or 158.