Controlled release formulations of octreotide
View Patent ↗A formulation of octreotide or pharmaceutically acceptable salts thereof, which provides controlled release of a therapeutically effective amount of octreotide for a period of at least about two months. Methods of treating acromegaly, decreasing growth hormone, decreasing IGF-1, and treating conditions associated with carcinoid tumors and VIPomas by administering a controlled release formulation of octreotide are provided herein.
1. An implant comprising a hydrogel and octreotide, wherein said octreotide is contained within said hydrogel, wherein said hydrogel comprises a copolymer obtained from the copolymerization of a mixture comprising at least two hydrophilic, ethylenically unsaturated-monomers, wherein said implant contains from about 20 to about 150 milligrams of octreotide, in free form or salt form, wherein said implant further comprises hydroxypropylcellulose, and wherein said implant provides an in vivo average C ss of about 0.1 ng/ml to about 9 ng/ml of octreotide in a patient over a period of at least about two months.
2. The implant of claim 1 , wherein said octreotide is octreotide acetate.
3. The implant of claim 2 , which contains about 50 milligrams of octreotide acetate.
4. The implant of claim 2 , which contains about 80 milligrams of octreotide acetate.
5. The implant of claim 1 , which provides an in vivo average C ss of about 1 ng/ml to about 2 ng/ml of octreotide in a patient.
6. The implant of claim 1 , which releases octreotide over a period of at least about six months.
7. The implant of claim 1 , wherein said hydrophilic, ethylenically unsaturated monomers are selected from monoalkylene and polyalkylene polyols of methacrylic acid and acrylic acid monomers.
8. The implant of claim 1 , wherein said hydrophilic, ethylenically unsaturated monomers are selected from 2-hydroxyethyl methacrylate and hydroxypropyl methacrylate monomers.
9. The implant of claim 1 , wherein said copolymer comprises about 20% of 2-hydroxyethyl methacrylate units and about 80% hydroxypropyl methacrylate units.
10. The implant of claim 9 , which further comprises about 0.5 to about 5% w/w of magnesium stearate.
11. A method of treating acromegaly or one or more symptoms associated with acromegaly, said method comprising implanting subcutaneously into a patient in need thereof at least one implant comprising a hydrogel and octreotide, wherein said octreotide is contained within said hydrogel, wherein said hydrogel comprises a copolymer obtained from the copolymerization of a mixture comprising at least two hydrophilic, ethylenically unsaturated-monomers, wherein said implant contains between about 20 to about 150 milligrams of octreotide in free form or salt form, wherein said implant further comprises hydroxypropylcellulose, and wherein said implant releases an effective amount of octreotide to said patient over a period of at least about two months.
12. The method of claim 11 , wherein said at least one implant comprises about 50 milligrams of octreotide acetate.
13. The method of claim 11 , wherein said at least one implant comprises about 80 milligrams of octreotide acetate.
14. The method of claim 11 , wherein two or more implants are implanted subcutaneously.
15. The method of claim 11 , wherein said at least one implant is implanted subcutaneously every about six months.
16. An implant comprising octreotide in free form or salt form, and hydroxypropylcellulose, wherein said octreotide and said hydroxypropylcellulose are contained within a hydrogel comprising a hydrophilic copolymer obtained from the copolymerization of a mixture comprising at least two hydrophilic, ethylenically unsaturated monomers, wherein said implant releases octreotide at a rate of about 30 μg to about 250 μg per day over a period of about six months in vitro.
17. The implant of claim 16 , which releases octreotide at an average rate of about 100 μg per day in vitro.
18. The implant of claim 16 , wherein said octreotide is octreotide acetate.
19. The implant of claim 1 , wherein said copolymer comprises about 40% of 2-hydroxyethyl methacrylate units and about 60% hydroxypropylmethacrylate units.
20. The implant of claim 1 which contains about 0.5 to about 20% w/w of hydroxypropylcellulose.
21. The implant of claim 1 which contains about 10% w/w of hydroxypropylcellulose.
22. The implant of claim 21 which contains about 2% w/w of magnesium stearate.
23. The method of claim 11 in which said implant is formed by a multi-step process that includes irradiation.
24. The method of claim 11 in which said implant is formed by a multi-step process that includes little to no priming.
25. The method of claim 11 in which said implant is implanted subcutaneously in a hydrated state.
26. The method of claim 11 in which said controlled release formulation is implanted subcutaneously in a dry state.
27. An implant comprising a hydrogel, octreotide in free form or salt form, and hydroxypropylcellulose, wherein said octreotide and said hydroxypropylcellulose are contained within said hydrogel, said hydrogel comprising a hydrophilic copolymer obtained from the copolymerization of a mixture comprising at least two hydrophilic, ethylenically unsaturated monomers, wherein said implant releases said octreotide at a rate of about 10 μg to about 1000 μg per day over a period of about six months.
28. The implant of claim 27 , wherein said implant releases said octreotide at a rate of about 20 μg to about 800 μg per day over a period of about six months.