System and method for early identification of safety concerns of new drugs
Method and system for identifying safety concerns regarding a new drug. In one example, a database of healthcare claims is utilized and the method may include identifying from the database a first group of patients that have received the drug; extracting one or more medical events that the first group of patients have experienced; identifying a second group of patients that have received a comparator drug; extracting one or more medical events that the second group of patients have experienced; and comparing the one or more medical events of the first group to the one or more medical events of the second group to determine one or more common occurrences therebetween. The method may also include computing a probability value for each of the one or more common occurrences. In this way, embodiments of the present invention may be used to identify and quantify the probability that certain medical events will occur to patients taking the new drug.
1. A computer-implemented system for administering a drug registry database, comprising:
an electronic database containing a plurality of healthcare claims for a plurality of patients and a plurality of new drug/comparator drug pairs predefined by a system administrator, wherein the predefined new drug/comparator drug pairs each include a new drug for which a threshold number of healthcare claims have been stored and a comparator drug that has substantially similar medical indications as the new drug;
an electronic user interface configured to
display the stored plurality of new drug/comparator drug pairs; and
receive a selection of at least one of the displayed new drug/comparator drug pairs and filter parameters input by a user; and
a computer-implemented analysis engine configured to
search the healthcare claims stored in the database in response to the received selection to identify a first and second group of patients satisfying the filter parameters input by the user, wherein the first group includes patients with claim data indicating use of the new drug and the second group includes patients with claim data indicating use of the comparator drug;
identify a comparative occurrence of one or more existing medical conditions or new medical conditions in the first and second groups of patients; and
calculate a probability value indicating a relative likelihood that a patient taking the new drug will have each of the one or more new or existing medical conditions in comparison to a likelihood that a patient taking the comparator drug will have each of the one or more new or existing medical conditions;
wherein the electronic user interface displays each new or existing medical condition and the probability value for the new drug and the comparator drug in accordance with one or more report parameters entered by the user.
2. The system according to claim 1 , wherein the display generated by the user interface further includes demographic characteristics, prevalence of diagnosis, prevalence of procedures, prevalence of drug class, or healthcare utilization.
3. The system according to claim 1 , wherein the filter parameters include one or more diagnosis codes, procedure codes, drug categories, or demographic characteristics.
4. A computer-implemented method for administering a drug registry database, comprising a computer performing the following:
storing in an electronic database containing a plurality of healthcare claims for a plurality of patients and a plurality of new drug/comparator drug pairs predefined by a system administrator, wherein the predefined new drug/comparator drug pairs each include a new drug for which a threshold number of healthcare claims have been stored and a comparator drug that has substantially similar medical indications as the new drug;
displaying the stored plurality of new drug/comparator drug pairs on an electronic user interface;
receiving a selection of at least one of the displayed new drug/comparator drug pairs and filter parameters input by the user via the electronic user interface;
searching the healthcare claims stored in the database in response to the received selection using a computer-implemented analysis engine to identify a first and second group of patients satisfying the filter parameters input by the user, wherein the first group includes patients with claim data indicating use of the new drug and the second group includes patients with claim data indicating use of the comparator drug;
using the analysis engine to identify a comparative occurrence of one or more existing medical conditions or new medical conditions in the first and second groups of patients;
using the analysis engine to calculate a probability value indicating a relative likelihood that a patient taking the new drug will have each of the one or more new or existing medical conditions in comparison to a likelihood that a patient taking the comparator drug will have each of the one or more new or existing medical conditions; and
displaying on the electronic user interface each new or existing medical condition and the probability value for the new drug and the comparator drug in accordance with one or more report parameters entered by the user.
5. The method according to claim 4 , wherein the display on the user interface further includes demographic characteristics, prevalence of diagnosis, prevalence of procedures, prevalence of drug class, or healthcare utilization.
6. The method according to claim 4 , wherein the filter parameters include one or more diagnosis codes, procedure codes, drug categories, or demographic characteristics.