Carboxylic acid derivatives, their preparation and their use
View Patent ↗A compound of the formula pharmaceutically acceptable salts and enantiomers thereof and pharmaceutical compositions containing this compound, its pharmaceutically acceptable salts and enantiomers are claimed.
1. The compound
2. A compound of the formula:
wherein:
X is CH;
Y is oxygen;
Z is oxygen;
R is CO 2 H;
R 2 is methoxy;
R 3 is methoxy;
R 4 is phenyl;
R 5 is phenyl;
R 6 is methyl,
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 2 , wherein said compound is an optically active enantiomer.
4. The compound of claim 3 , wherein the enantiomer is the S enantiomer.
5. The compound of claim 4 , wherein the enantiomer is the pure form of the S enantiomer.
6. The compound of claim 3 , wherein the enantiomer is the R enantiomer.
7. The compound of claim 6 , wherein the enantiomer is the pure form of the R enantiomer.
8. A pharmaceutical composition comprising a compound having the formula:
wherein:
X is CH;
Y is oxygen;
Z is oxygen;
R is CO 2 H;
R 2 is methoxy;
R 3 is methoxy;
R 4 is phenyl;
R 5 is phenyl;
R 6 is methyl; or a
pharmaceutically acceptable salt thereof,
and a pharmaceutically acceptable carrier.
9. The composition of claim 8 , wherein said composition is suitable for oral, parenteral, or nasopharyngeal delivery.
10. The composition of claim 8 , wherein the composition is in a solid form.
11. The composition of claim 8 , wherein the composition is in a liquid form.
12. The composition of claim 8 , wherein the composition is in the form of a tablet, capsule, powder, granule, suppository, solution, colloid, ointment, cream, vapor or spray.
13. The composition of claim 8 , wherein the carrier comprises a tablet binder, filler, preservative, tablet disintegrant, flow regulator, plasticizer, wetting agent, dispersant, emulsifier, solvent, release-slowing agent, antioxidant, or propellant gas.
14. The composition of claim 8 , wherein the compound is an optically active enantiomer.
15. The composition of claim 14 , wherein the enantiomer is the S enantiomer.
16. The composition of claim 15 , wherein the enantiomer is the pure form of the S enantiomer.
17. The composition of claim 14 , wherein the enantiomer is the R enantiomer.
18. The composition of claim 17 , wherein the enantiomer is the pure form of the R enantiomer.