Augmentation of titer for vaccination in animals
View Patent ↗The disclosure relates to a composition added to animal feed used in combination with a vaccine to enhance the effectiveness of the vaccine. Amongst other effects, the composition raises the titer of antibodies to the vaccine.
1. A method for vaccinating an individual, comprising:
administering a composition comprising β-glucan, β-1,3(4)-endoglucanohydrolase, calcined diatomaceous earth, a mineral clay, and glucomannan to an individual of a mammalian species or an avian species prior to administering a dose of a vaccine to the individual; and
vaccinating the individual with the vaccine, wherein the individual subsequently has an increased titer of antibodies to the vaccine relative to a titer of antibodies to the vaccine if the composition had not been administered.
2. The method of claim 1 wherein said composition is administered daily to said individual.
3. The method of claim 1 wherein said composition is added to the feed of the individual in the range of from about 0.01% to about 2.5% by weight of said feed on a dry weight basis.
4. The method of claim 1 wherein said composition is added to the feed of said individual in the range of from about 0.01 gram per kilogram of live body weight of said individual to 1 gram per kilogram of live body weight.
5. The method of claim 1 wherein the individual subsequently has an increased titer of the IgG1 or IgG2 classes of antibodies relative to a titer of said IgG1 or IgG2 antibodies if said composition had not been administered.
6. The method of claim 1 wherein the individual subsequently has an increased titer of IgG2 class antibodies relative to a titer of said IgG2 antibodies if said composition had not been administered.
7. The method of claim 1 wherein the individual is a bovine, and said vaccine and said composition are administered to said bovine.
8. The method of claim 1 wherein said individual is a bovine, and said composition is administered to said bovine in the range of from about 10 grams to about 60 grams per day per animal.
9. The method of claim 1 wherein said individual is a sheep, and said vaccine and said composition are administered to said sheep.
10. The method of claim 1 wherein said individual is a sheep, and said composition is administered to said sheep in the range of from about 2 grams to about 10 grams per day per animal.
11. The method of claim 1 wherein said individual is vaccinated with a vaccine that stimulates the production of antibodies to an infectious agent that causes mastitis.
12. The method of claim 1 wherein said vaccine is the J5 vaccine.
13. The method of claim 1 wherein the composition is administered daily for at least 7 days prior to administering the dose of the vaccine.
14. The method of claim 1 , further comprising administering the composition after administering the dose of the vaccine and prior to administering one or more subsequent doses of the vaccine.
15. The method of claim 1 wherein said vaccine is a vaccine for infectious bovine rhinotracheitis, parainfluenza type 3, bovine virus diarrhea virus, bovine respiratory syncytial virus, rota virus, corona virus, Campylobacter spp., Pasteurella spp., pinkeye, Salmonella spp., Clostridium spp., Leptospirosis , Brucellosis, Newcastle disease, fowl pox, erysipelas, fowl cholera, Marek's Disease Virus, Infectious Bronchitis Virus, avian encephalomyelitis, coccidiosis, rhinopneumonitis, equine influenza, Streptococcus equi , equine viral arteritis, equine monocytis ehrlichiosis, encephalomyelitis, West Nile encephalitis, rabies, parvovirus, adenovirus, Bordetella , Lyme disease, Giardia , pertussus, measles virus, hepatitis A, hepatitis B, diphtheria, or poliomyelitis.
16. The method of claim 1 wherein said composition is mixed with solid feed, liquid feed, or water.
17. A method for vaccinating an individual, comprising:
administering a composition comprising β-glucan, β-1,3(4)-endoglucanohydrolase, calcined diatomaceous earth, a mineral clay, and glucomannan to an individual of a mammalian species or an avian species prior to administering a dose of a vaccine to the individual; and
providing the individual to a vaccinator, wherein the vaccinator vaccinates the individual with the vaccine, and wherein the individual subsequently has an increased titer of antibodies to the vaccine relative to a titer of antibodies to the vaccine if the composition had not been administered.
18. A method for vaccinating an individual, comprising:
receiving an individual of a mammalian species or an avian species, wherein a composition comprising (β-glucan, β-1,3(4)-endoglucanohydrolase, calcined diatomaceous earth, a mineral clay, and glucomannan was administered to the individual prior to administering a dose of a vaccine to the individual; and
vaccinating the individual with the vaccine, wherein the individual subsequently has an increased titer of antibodies to the vaccine relative to a titer of antibodies to the vaccine if the composition had not been administered.