Bicycloheteroaryl compounds as P2X
Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
1. A bicycloheteroaryl compound capable of modulating P2X 7 receptor activity, in vivo, having a formula:
wherein
A is selected from CR 2a R 2b ;
B and Y are independently selected from CR 2a and CR 2a R 2b ;
Z is CR 4 ;
L 1 is a bond, —CO—, —SO 2 — or a C 1 -C 5 alkylene group which can be optionally substituted by a substituent selected from alkyl, hydroxy, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, halogen, carbamoyl, and C 1 -C 6 alkoxy;
n is 0, 1, 2 or 3;
R 1 is selected from a 3-13 membered cycloalkyl, which can be optionally substituted with one or more substituents independently selected from halo, hydroxyl, amino, cyano, sulfo, sulfanyl, sulfinyl, amido, carboxy, ester, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, and sulfonamido;
each of R 2a , R 2b , R 2′ and R 2″ is independently selected from hydrogen, substituted or unsubstituted C 1 -C 6 alkyl; or any of R 2′ and R 2″ can join together to form a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms;
R 3 is selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted bicycloaryl, and substituted or unsubstituted bicycloheteroaryl; provided when R 3 is hydrogen, L 1 is a bond or a C 1 -C 5 alkylene group;
R 4 is selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio;
and the dotted bond is a single or a double bond;
or a pharmaceutically acceptable salt thereof;
and stereoisomers and tautomers thereof.
2. A compound according to claim 1 wherein each of A, B, Y is CR 2a R 2b ; and the dotted bond is a single bond.
3. A compound according to claim 1 wherein each of A, B, Y is CH 2 ; and the dotted bond is a single bond.
4. A compound according to claim 1 wherein A is CR 2a R 2b ; and each of B and Y is CR 2a ; and the dotted bond is a double bond.
5. A compound according to claim 1 wherein A is CH 2 ; and each of B and Y is CH; and the dotted bond is a double bond.
6. A compound according to claim 1 wherein each of R 2′ and R 2″ of the
group is H.
7. A compound according to claim 3 wherein one of R 2′ and R 2″ of the
group is Me and the other is H.
8. A compound according to claim 1 wherein each of R 2′ and R 2″ of the
group is Me.
9. A compound according to claim 1 wherein the
group is selected from substituted or unsubstituted
10. A compound according to claim 1 wherein the
group is
and wherein R a , R b and R c are independently selected from H, halo, hydroxyl, substituted hydroxyl, alkyl, substituted alkyl, amino, substituted amino, aryl and substituted aryl.
11. A compound of claim 10 wherein R a , R b and R c are independently selected from H, Br, Cl, OH, Me, NHAc, Ph and F.
12. A compound of claim 10 wherein each of R a , R b and R c is H.
13. A compound according to claim 1 wherein the compound is depicted by a formula
and wherein L 1 , R 3 , Z, and n are as described in claim 1 ; and wherein R a , R b and R c are independently selected from H, halo, hydroxyl, substituted hydroxyl, alkyl, substituted alkyl, amino, substituted amino, aryl and substituted aryl.
14. A compound according to claim 13 wherein n is 0.
15. A compound according to claim 13 wherein n is 1.
16. A compound of claim 13 wherein each of R a , R b and R c is H.
17. A compound of claim 13 wherein each of R a , R b and R c is Me.
18. A compound of claim 13 wherein two of R a , R b and R c is Me.
19. A compound of claim 13 wherein one of R a , R b and R c is OH.
20. A compound according to either of claims 1 or 13 wherein L 1 is a bond and R 3 is H.
21. A compound according to either of claims 1 or 13 wherein L 1 is a C 1 -C 5 alkylene group which can be optionally substituted by a substituent selected from alkyl, hydroxy, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, halogen, carbamoyl, and C 1 -C 6 alkoxy; and R 3 is H.
22. A compound according to either of claims 1 or 13 wherein L 1 is —CO—, or —SO 2 —.
23. A compound according to either of claims 1 or 13 wherein L 1 is a C 1 -C 5 alkylene group which can be optionally substituted by a substituent selected from alkyl, hydroxy, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, halogen, carbamoyl, and C 1 -C 6 alkoxy.
24. A compound according to either of claims 1 or 13 wherein L 1 is a C 1 -C 5 alkylene group, —CO—, or —SO 2 —; and R 3 is substituted or unsubstituted alkyl.
25. A compound according to either of claims 1 or 13 wherein L 1 is a C 1 -C 5 alkylene group, —CO—, or —SO 2 —; and R 3 is substituted alkyl and the substitution on alkyl is selected from aryl, heteroaryl, cycloalkyl, heterocycloalkyl, halo, alkoxy, hydroxy, cyano, and aryloxy.
26. A compound according to either of claims 1 or 13 wherein L 1 is a C 1 -C 5 alkylene group, —CO—, or —SO 2 —; and R 3 is substituted alkyl and the substitution on alkyl is selected from Ph, Cl, F, Br, CN, OH, OMe, OPh, CF 3 , CHF 2 , OCF 3 , t-Bu, SMe, SOMe, SO 2 Me, SO 3 H, SO 3 Me, pyridyl, cyclopropyl, cyclopentyl and cyclohexyl.
27. A compound according to either of claims 1 or 13 wherein L 1 is a C 1 -C 5 alkylene group, —CO—, or —SO 2 —; and R 3 is
and wherein n′ is selected from 1-5 and each of R 4′ is independently selected from hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, aryloxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio.
28. A compound according to claim 27 wherein n′ is 1, 2 or 3.
29. A compound according to claim 27 wherein each R 4′ is independently selected from Me, Et, Ph, Cl, F, Br, CN, OH, OMe, OPh, COPh, CF 3 , CHF 2 , OCF 3 , t-Bu, SMe, CH═CH—CO 2 H, SOMe, SO 2 Me, SO 3 H, SO 3 Me, and pyridyl.
30. A compound according to either of claims 1 or 13 wherein L 1 is a C 1 -C 5 alkylene group, —CO—, or —SO 2 —; R 3 is substituted or unsubstituted cycloalkyl, heterocycloalkyl, heteroaryl, bicycloaryl or bicycloheteroaryl.
31. A compound according to either of claims 1 or 13 wherein L 1 is a C 1 -C 5 alkylene group, —CO—, or —SO 2 —; R 3 is substituted or unsubstituted naphthalene, furanyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, pyridyl, pyrimidinyl, quinoline, isoquinolinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, indolyl, benzopyranyl, benzofuranyl, benzoxazinyl, or benzodioxanyl.
32. A compound according to either one of claims 1 or 13 wherein each of Z is CH.
33. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of claim 1 .
34. The pharmaceutical composition of claim 33 , wherein the carrier is a parenteral carrier.
35. The pharmaceutical composition of claim 33 , wherein the carrier is an oral carrier.
36. The pharmaceutical composition of claim 33 , wherein the carrier is a topical carrier.
37. A compound according to claim 1 wherein the compound is selected from
Name
5,6,7,8-Tetrahydro-pyrido[3,4-d]pyrimidine-4-carboxylic acid
cyclohexylmethyl-amide;
7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-carboxylic
acid cyclohexylmethyl-amide;
7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-carboxylic
acid (adamantan-1-ylmethyl)-amide;
7-Pyridin-3-ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid cyclohexylmethyl-amide;
7-Pyridin-4-ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid cyclohexylmethyl-amide;
7-(2-Chloro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid cyclohexylmethyl-amide;
7-(4-Chloro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid cyclohexylmethyl-amide;
7-Pyridin-2-ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid cyclohexylmethyl-amide;
7-(3-Chloro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid cyclohexylmethyl-amide;
7-(4-Methoxy-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid cyclohexylmethyl-amide;
7-(4-Methyl-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid cyclohexylmethyl-amide;
7-(4-Methanesulfonyl-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidine-4-carboxylic acid cyclohexylmethyl-amide;
7-(4-Acetylamino-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidine-4-carboxylic acid cyclohexylmethyl-amide;
7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-carboxylic
acid (1-hydroxy-cycloheptylmethyl)-amide;
7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-carboxylic
acid (1-hydroxy-3,3-dimethyl-cyclohexylmethyl)-amide;
7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-carboxylic
acid (1-p-tolyl-cyclohexylmethyl)-amide;
7-(2-4-Difluoro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-
4-carboxylic acid (adamantan-1-ylmethyl)-amide;
7-(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidine-4-carboxylic acid (adamantan-1-ylmethyl)-
amide;
7-(2-Fluoro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid (adamantan-1-ylmethyl)-amide;
7-(3-Fluoro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid (adamantan-1-ylmethyl)-amide;
7-(3-Methoxy-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid (adamantan-1-ylmethyl)-amide;
7-(2-Methyl-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid (adamantan-1-ylmethyl)-amide;
7-(2-Chloro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid (adamantan-1-ylmethyl)-amide;
7-(4-Fluoro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine-4-
carboxylic acid (adamantan-1-ylmethyl)-amide;
7-Benzo[1,3]dioxol-5-ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidine-4-carboxylic acid (adamantan-1-ylmethyl)-amide;
2-Adamantan-1-yl-N-(7-benzyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-
yl)-acetamide;
2-Adamantan-1-yl-N-(7-methyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-(7-ethyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-acetamide;
N-(7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-2-
cyclohexyl-acetamide;
N-(7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-2-
cycloheptyl-acetamide;
2-Cyclohexyl-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-
acetamide;
2-Cycloheptyl-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-
acetamide;
2-Adamantan-1-yl-N-[7-(2-hydroxy-3-methoxy-propyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-phenethyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(4-methanesulfonyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-pyridin-3-ylmethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(2-hydroxy-ethyl)-5,6,7,8-tetrahydro-
pyrido(3,4-d]pyridin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-hydroxy-propyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyridin-4-yl]-acetamide;
2-Cyclohexyl-N-(7-ethyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-
4-yl)-acetamide;
2-Cyclohexyl-N-[7-(3-hydroxy-propyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Cyclohexyl-N-[7-(2-hydroxy-ethyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,3-dihydroxy-propyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Cyclohexyl-N-(7-methyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-methoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-dimethoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-methyl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,5-dimethyl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-chloro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-methoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-dimethoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5-dimethoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-methoxy-3-methyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-methoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-chloro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-cyano-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-pyridin-4-ylmethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(4-methyl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-ethyl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-difluoro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-pyridin-2-ylmethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
N-[7-(4-Acetylamino-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-adamantan-1-yl-acetamide;
2-Adamantan-1-yl-N-[7-(3-phenyl-propyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(1H-indol-5-ylmethyl)-5,6,7,8-tetrahydro-
pyrido[3-4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-pyridin-2-yl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-methyl-thiophen-2-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(1-methyl-1H-imidazol-2-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-phenoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-quinolin-4-ylmethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(3-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-tert-butyl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-quinolin-2-ylmethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(4-trifluoromethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-phenoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-trifluoromethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-difluoromethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-difluoromethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-phenyl-thiophen-2-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-butyl-1H-imidazol-4-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-methyl-3H-imidazol-4-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(1H-imidazol-4-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-chloro-thiophen-2-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-cyano-4-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-4-methyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-fluoro-3-methyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(6-chloro-2-fluoro-3-methyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-(2-chloro-6-fluoro-3-methyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-{4-[(2-hydroxy-ethyl)-methyl-amino]-
benzyl}-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(2,2-difluoro-benzo[1,3]dioxol-4-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-{4-[4-(2-Adamantan-1-yl-acetylamino)-5,8-dihydro-6H-pyrido[3,4
d]pyrimidin-7-ylmethyl]-phenoxy}-acetamide;
2-{2-[4-(2-Adamantan-1-yl-acetylamino)-5,8-dihydro-6H-pyrido[3,4-
d]pyrimidin-7-ylmethyl]-phenoxy}-acetamide;
2-Cycloheptyl-N-(7-pyridin-3-ylmethyl-5,6,7,8-tetrahydro-
pyrido(3,4-d]pyrimidin-4-yl)-acetamide;
2-Cycloheptyl-N-(7-pyridin-2-ylmethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-4-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-fluoro-2-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-4-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-imidazol-1-yl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-{7-[4-(2-hydroxy-ethoxy)-benzyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-{7-[2-(2-hydroxy-ethoxy)-benzyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-{7-[3-(2-hydroxy-ethoxy)-benzyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-[7-(5-fluoro-2-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-fluoro-3-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-5-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,3-dihydro-benzofuran-5-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide
2-Adamantan-1-yl-N-[7-(4-fluoro-3-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-fluoro-2-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-5-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-5-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-4-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-6-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-methyl-naphthalen-1-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-isopropoxy-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-trifluoromethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
(E)-3-{4-[4-(2-Adamantan-1-yl-acetylamino)-5,8-dihydro-6H-
pyrido[3,4-d]pyrimidin-7-ylmethyl]-phenyl}-acrylic acid;
2-Adamantan-1-yl-N-[7-(4-methylsulfanyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-hydroxy-3-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(6-methyl-pyridin-2-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-4-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-cyclopentylmethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-(7-cyclohexylmethyl-5,6,7,8-tetrahydro-
pyrido[3-4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Cycloheptyl-N-[7-(3-phenyl-propyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-acetamide;
2-Cycloheptyl-N-[7-(5-methyl-thiophen-2-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Cycloheptyl-N-[7-(1H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Cycloheptyl-N-(7-cyclohexylmethyl-5,6,7,8-tetrahydro-pyrido(3-4-
d]pyrimidin-4-yl)-acetamide;
2-Cycloheptyl-N-(7-cyclopentylmethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Cycloheptyl-N-(7-phenethyl-5,6,7,8-tetrahydro-pyrido(3,4-
d]pyrimidin-4-yl)-acetamide;
2-Cycloheptyl-N-[7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-3-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
{4-[4-(2-Adamantan-1-yl-acetylamino)-5,8-dihydro-6H-pyrido[3,4-
d]pyrimidin-7-ylmethyl]-phenoxy}-acetic acid;
{2-[4-(2-Adamantan-1-yl-acetylamino)-5,8-dihydro-6H-pyrido[3,4-
d]pyrimidin-7-ylmethyl]-phenoxy}-acetic acid;
2-Adamantan-1-yl-N-(7-methanesulfonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-(7-benzenesulfonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(toluene-4-sulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(naphthalene-2-sulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(quinoline-8-sulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(propane-1-sulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-ethanesulfonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(4-methoxy-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-chloro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-dimethoxy-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-phenylmethanesulfonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(3-trifluoromethyl-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-dichloro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-trifluoromethoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-methyl-3,4-dihydro-2H-
benzo[1,4]oxazine-7-sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-chloro-1,3-dimethyl-1H-pyrazole-4-
sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-methyl-2-trifluoromethyl-furan-3-
sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-methyl-1-phenyl-1H-pyrazole-4-
sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-trifluoromethoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-methoxy-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(1-methyl-1H-imidazole-4-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(1,2-dimethyl-1H-imidazole-4-sulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-4-cyano-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-cyano-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-chloro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5-dimethyl-isoxazole-4-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-methanesulfonylmethanesulfonyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(2-oxo-2H-chromene-6-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-[4-(pyridin-2-yloxy)-benzenesulfonyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-{7-[4-(pyridin-3-yloxy)-benzenesulfonyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-{7-[4-(pyridin-4-yloxy)-benzenesulfonyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-{7-[4-(4-methoxy-phenoxy)-benzenesulfonyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-{7-[4-(3,4-dichloro-phenoxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
acetamide;
2-Adamantan-1-yl-N-{7-[4-(4-trifluoromethyl-phenoxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
acetamide;
2-Adamantan-1-yl-N-{7-[3-(3,4-dichloro-phenoxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
acetamide;
2-Adamantan-1-yl-N-[7-(4[40 -methoxy-biphenyl-4-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(pyridine-3-sulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-5-trifluoromethyl-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
acetamide;
2-Adamantan-1-yl-N-[7-(3,5-bis-trifluoromethyl-
phenylmethanesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-
4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-trifluoromethyl-phenylmethanesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-fluoro-phenylmethanesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-dichloro-phenylmethanesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5-dichloro-phenylmethanesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-trifluoromethyl-phenylmethanesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-p-tolylmethanesulfonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(4-chloro-phenylmethanesulfonyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-difluoromethoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-phenoxy-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-chloro-4-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(biphenyl-2-sulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-trifluoromethyl-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-pyrazol-1-yl-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-dimethoxy-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(1,3,5-trimethyl-1H-pyrazole-4-sulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(toluene-2-sulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,3-dihydro-benzo[1,4]dioxine-6-sulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-trifluoromethyl-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-chloro-2-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,5-difluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,5-dichloro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-chloro-2-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,6-difluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-chloro-4-methyl-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5-dichloro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-difluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,6-dichloro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-4-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-fluoro-2-methyl-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(propane-2-sulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-methoxy-5-methyl-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,5-dimethoxy-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5-dimethyl-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,6-dichlorobenzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
N-(7-Acetyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-2-
adamantan-1-yl-acetamide;
2-Adamantan-1-yl-N-(7-benzoyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(biphenyl-4-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3-4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-pyridine-3-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-propionyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-{7-[2-(4-methoxy-phenyl)-acetyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl -acetamide;
2-Adamantan-1-yl-N-(7-phenylacetyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(4-chloro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-trifluoromethoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-ethyl-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-methyl-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-cyclopentyl-propionyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-difluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-trifluoromethyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-methoxy-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5,5-trimethyl-hexanoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-diphenylacetyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(pyridine-3-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-cyclopentanecarbonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-{7-[2-(2-5-dimethoxy-phenyl)-acetyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-[7-(2-methoxy-acetyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-{7-[2-(4-fluoro-phenyl)-acetyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-[7-(3-cyano-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-trifluoromethyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-cyclohexanecarbonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-dichloro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5-dimethoxy-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,6-difluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-phenyl-propionyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-phenoxy-acetyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-methoxy-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-fluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,2-dimethyl-propionyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-chloro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-{7-[2-(3-4-dimethoxy-phenyl)-acetyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-[7-(3-methyl-butyryl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-benzyloxy-acetyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-cyano-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-dichlom-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(quinoxaline-2-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-cyclopropanecarbonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-{7-[2-(3-methoxy-phenyl)-acetyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-[7-(3,3-dimethyl-butyryl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-cyclopentyl-acetyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-{7-[2-(4-chloro-phenoxy)-acetyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-{7-[2-(4-chloro-phenyl)-acetyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-4-trifluoromethyl-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-5-trifluoromethyl-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-trifluoromethoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-trifluoromethoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-trifluoromethyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-5-trifluoromethyl-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-6-fluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-
carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-phenoxy-pyridine-3-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-dimethoxy-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,3-dihydro-benzo[1,4]dioxine-2-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3-4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-difluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-methyl-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,5-difluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-fluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(6-chloro-pyridine-3-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,3-dichloro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-methyl-isoxazole-3-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(1,5-dimethyl-1H-pyrazole-3-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,5-dimethyl-2H-pyrazole-3-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(1-phenyl-5-trifluoromethyl-1H-pyrazole-4-
carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-methyl-5-phenyl-furan-3-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-methyl-1-phenyl-1H-pyrazole-4-
carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-{7-[5-(4-chloro-phenyl)-2-methyl-furan-3-
carbonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
acetamide;
2-Adamantan-1-yl-N-[7-(naphthalene-2-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-methyl-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-methoxy-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,5-dimethyl-furan-3-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide:
2-Adamantan-1-yl-N-[7-(2-chloro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
N-[7-(1-Acetyl-piperidine-4-carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-adamantan-1-yl-acetamide;
2-Adamantan-1-yl-N-[7-(isoxazole-5-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5-dimethyl-isoxazole-4-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-pyridine-4-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(5-methyl-isoxazole-4-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-tert-butyl-5-methyl-2H-pyrazole-3-
carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-tert-butyl-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-{7-[2-(2-bromo-phenyl)-acetyl]-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-[7-(quinoline-2-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(pyridine-4-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(pyridine-2-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-{7-[1-(2,2,2-trifluoro-acetyl)-pyrrolidine-2-
carbonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
acetamide;
2-Adamantan-1-yl-N-[7-(3-methoxy-propionyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(pyrazine-2-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,3-dihydro-benzofuran-5-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-fluoro-4-methoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(quinoxaline-6-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-dimethoxy-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3-4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(chroman-3-carbonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-5-fluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,5-dichloro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-{7-[1-(2,3-dihydro-benzo[1,4]diaxin-6-yl)-
ethyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-acetamide;
2-Adamantan-1-yl-N-[7-(9H-fluoren-2-ylmethyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-dichloro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-dimethyl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-(7-benzo[1,3]dioxol-5-ylmethyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-difluoro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-chloro-4-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3-chloro-4-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-chloro-3-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2-chloro-4-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(2,4-bis-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-chloro-2-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-chloro-3-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(4-benzyloxy-2-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
4-{4-[4-(2-Adamantan-1-yl-acetylamino)-5,8-dihydro-6H-pyrido[3,4-
d]pyrimidin-7-ylmethyl]-3-methoxy-phenoxy}-butyric acid;
2-Adamantan-1-yl-N-[7-(1H-indol-6-ylmethyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-Adamantan-1-yl-N-[7-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-
ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
Adamantane-1-carboxylic acid (7-benzyl-5,6,7,8-tetrahydro-
pyrido[3-4-d]pyrimidin-4-yl)-amide;
2-Adamantan-1-yl-N-(7-benzyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-isobutyramide;
N-(7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-2-(3,5-
dimethyl-adamantan-1-yl)-acetamide;
N-(7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-2-(3,5-
dimethyl-adamantan-1-yl)-isobutyramide;
N-(7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-2-
(3,5,7-trimethyl-adamantan-1-yl)-acetamide;
N-(7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-2-
(3,5,7-trimethyl-adamantan-1-yl)-isobutyramide;
3,5,7-Trimethyl-adamantane-1-carboxylic acid (7-benzyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
2-Adamantan-1-yl-N-[7-(2,4-difluoro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2-chloro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2-methyl-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(1H-indol-6-ylmethyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-(7-phenylmethanesulfonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-isobutyl-amide;
2-Adamantan-1-yl-N-[7-(3-chloro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(3,4-difluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(3,4-dichloro-phenylmethanesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(4-chloro-phenylmethanesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(3-methyl-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyl-amide;
2-Adamantan-1-yl-N-[7-(3-trifluoromethyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(3,4-dichloro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2,6-difluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2-chloro-6-fluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2,5-difluoro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2,3-dichloro-benzoyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2-cyclopentyl-acetyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-(7-cyclohexanecarbonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-isobutyramide;
2-Adamantan-1-yl-N-[7-(3,3-dimethyl-butyryl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
2-Adamantan-1-yl-N-[7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-isobutyramide;
N-[7-(2-Chloro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-
yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
2-(3,5-Dimethyl-adamantan-1-yl)-N-[7-(2-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-(3,5-Dimethyl-adamantan-1-yl)-N-[7-(2-methyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
N-[7-(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-
acetamide;
N-[7-(2-4-Difluoro-benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
2-(3,5-Dimethyl-adamantan-1-yl)-N-[7-(1H-indol-6-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-(3,5-Dimethyl-adamantan-1-yl)-N-[7-(4-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyridol[3,4-d]pyrimidin-4-yl]-acetamide;
2-(3,5-Dimethyl-adamantan-1-yl)-N-(7-phenylmethanesulfonyl-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-acetamide;
N-[7-(3,4-Dichloro-phenylmethanesulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-
acetamide;
N-[7-(4-Chloro-phenylmethanesulfonyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-
acetamide;
N-[7-(3-Chloro-benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
N-[7-(2,3-Difluoro-benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
2-(3,5-Dimethyl-adamantan-1-yl)-N-[7-(3-methyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
2-(3,5-Dimethyl-adamantan-1-yl)-N-[7-(3-trifluoromethyl-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
N-[7-(2-Cyclopentyl-acetyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
N-[7-(3,4-Dichloro-benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
N-(7-Cyclohexanecarbonyl-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl)-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
N-[7-(2,6-Difluoro-benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
2-(3,5-Dimethyl-adamantan-1-yl)-N-[7-(3,3-dimethyl-butyryl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-acetamide;
N-[7-(2-Chloro-6-fluoro-benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
N-[7-(2,5-Difluoro-benzoyl)-5,6,7,8-tetrahydro-pyrido[3-4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
N-[7-(2,3-Dichloro-benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-2-(3,5-dimethyl-adamantan-1-yl)-acetamide;
Adamantane-1-carboxylic acid [7-(2,6-dichloro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-acetyl-5,6,7,8-tetrahydro-
pyrido[3-4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid (7-benzoyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-pyridine-3-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-propionyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid {7-[2-(4-methoxy-phenyl)-acetyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid (7-phenylacetyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(4-chloro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-fluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-trifluoromethoxy-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3-4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-ethyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-methyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-cyclopentyl-propionyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,4-difluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-trifluoromethyl-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-methoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,5,5-trimethyl-hexanoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-diphenylacetyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid (7-cyclopentanecarbonyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid {7-[2-(2,5-dimethoxy-phenyl)-
acetyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid [7-(2-methoxy-acetyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid {7-[2-(4-fluoro-phenyl)-acetyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid [7-(3-cyano-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-trifluoromethyl-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-cyclohexanecarbonyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(3,4-dichloro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,5-dimethoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,6-difluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-phenyl-propionyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-phenoxy-acetyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-methoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-fluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,2-dimethyl-propionyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-chloro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid {7{2-(3-4-dimethoxy-phenyl)-
acetyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid [7-(3-methyl-butyryl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-benzyloxy-acetyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-cyano-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,4-dichloro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(quinoxaline-2-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-cyclopropanecarbonyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid {7-[2-(3-methoxy-phenyl)-acetyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid [7-(3,3-dimethyl-butyryl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-cyclopentyl-acetyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid {7-[2-(4-chloro-phenoxy)-acetyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid {7-[2-(4-chloro-phenyl)-acetyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid [7-(2-fluoro-4-trifluoromethyl-
benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-fluoro-5-trifluoromethyl-
benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-trifluoromethoxy-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-trifluoromethoxy-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-trifluoromethyl-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-5-trifluoromethyl-
benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-6-fluoro-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(5-methyl-2-phenyl-2H-
[1,2,3]triazole-4-carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-phenoxy-pyridine-3-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,4-dimethoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,3-dihydro-benzo[1,4]dioxine-2-
carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,4-difluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-methyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,5-difluoro-benzoyl)-5,6,7,8-
tetrahydro-pyridol[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-fluoro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(6-chloro-pyridine-3-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,3-dichloro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(5-methyl-isoxazole-3-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(1,5-dimethyl-1H-pyrazole-3-
carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-methyl-5-phenyl-furan-3-
carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(5-methyl-1-phenyl-1H-pyrazole-
4-carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid {7-[5-(4-chloro-phenyl)-2-methyl-
furan-3-carbonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
amide;
Adamantane-1-carboxylic acid [7-(naphthalene-2-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-methyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-methoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,5-dimethyl-furan-3-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(1-acetyl-piperidine-4-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(isoxazole-5-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-pyridine-4-carbonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-tert-butyl-5-methyl-2H-
pyrazole-3-carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-
yl]-amide;
Adamantane-1-carboxylic acid [7-(4-tert-butyl-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide
Adamantane-1-carboxylic acid {7-[2-(2-bromo-phenyl)-acetyl]-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid [7-(quinoline-2-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid {7-[1-(2,2,2-trifluoro-acetyl)-
pyrrolidine-2-carbonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-
yl}-amide;
Adamantane-1-carboxylic acid [7-(pyrazine-2-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,3-dihydro-benzofuran-5-
carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-fluoro-4-methoxy-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid 7-(3,4-dimethoxy-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(chroman-3-carbonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-5-fluoro-benzoyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,5-dichloro-benzoyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-methanesulfonyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid (7-benzenesulfonyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(toluene-4-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(naphthalene-2-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(quinoline-8-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(propane-1-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-ethanesulfonyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(4-methoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-chloro-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,4-dimethoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3-4-d]pyrimidin-4-yl]-amide:
Adamantane-1-carboxylic acid [7-(4-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-phenylmethanesulfonyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(3-trifluoromethyl-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(4-trifluoromethoxy-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(4-methyl-3,4-dihydro-2H-
benzo[1,4]oxazine-7-sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-
d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(5-chloro-1,3-dimethyl-1H-
pyrazole-4-sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(5-methyl-1-phenyl-1H-pyrazole-
4-sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-trifluoromethoxy-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(3-methoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(1,2-dimethyl-1H-imidazole-4-
sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-4-cyano-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(2-fluoro-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-cyano-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,5-dimethyl-isoxazole-4-
sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-methanesulfonylmethanesulfonyl-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(2-oxo-2H-chromene-6-sulfonyl)-
5,6,7,8-tetrahydro-pyrido[3-4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid {7-[4-(pyridin-2-yloxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
amide;
Adamantane-1-carboxylic acid {7-[4-(pyridin-3-yloxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
amide;
Adamantane-1-carboxylic acid {7-[4-(pyridin-4-yloxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
amide;
Adamantane-1-carboxylic acid {7-[4-{4-methoxy-phenoxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
amide;
Adamantane-1-carboxylic acid {7-[4-(4-trifluoromethyl-phenoxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
amide;
Adamantane-1-carboxylic acid {7-[3-(3,4-dichloro-phenoxy)-
benzenesulfonyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-
amide;
Adamantane-1-carboxylic acid [7-(4[40 -methoxy-biphenyl-4-sulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(pyridine-3-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-5-trifluoromethyl-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(3,5-bis-trifluoromethyl-
phenylmethanesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-
4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-trifluoromethyl-
phenylmethanesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-
4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-fluoro-phenylmethanesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,4-dichloro-
phenylmethanesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-
4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,5-dichloro-
phenylmethanesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-
4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-trifluoromethyl-
phenylmethanesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-
4-yl]-amide;
Adamantane-1-carboxylic acid (7-p-tolylmethanesulfonyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(4-chloro-phenylmethanesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3-4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-difluoromethoxy-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(4-phenoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-chloro-4-fluoro-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(biphenyl-2-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-trifluoromethyl-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(4-pyrazol-1-yl-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,4-dimethoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(1,3,5-trimethyl-1H-pyrazole-4-
sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-trifluoromethoxy-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(toluene-2-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,3-dihydro-benzo[1,4]dioxine-6-
sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-trifluoromethyl-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(4-chloro-2-fluoro-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(2,5-difluoro-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,5-dichloro-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(5-chloro-2-fluoro-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(2,6-difluoro-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-chloro-4-methyl-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(3,5-dichloro-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,4-difluoro-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,6-dichloro-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-4-fluoro-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(5-fluoro-2-methyl-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(propane-2-sulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-methoxy-5-methyl-
benzenesulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(2,5-dimethoxy-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3-4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,5-dimethyl-benzenesulfonyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-cyano-benzenesulfonyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,5,5-trimethyl-hexyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,2-diphenyl-ethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-phenyl-propyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-propyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid (7-cyclohexylmethyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid (7-cyclopropylmethyl-5,6,7,8-
tetrahydro-pyrido(3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid (7-pentyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(3-phenyl-propyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-pyridin-3-ylmethyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(1-methyl-1H-pyrrol-2-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(1H-indol-3-ylmethyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-benzo[1,3]dioxol-5-ylmethyl-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid (7-naphthalen-2-ylmethyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(3,4-dimethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(6-methyl-4-oxo-4H-chromen-3-
ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-phenoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(5-bromo-2-methoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,4-dichloro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-cyano-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-tert-butyl-benzyl)-5,6,7,8-
tetrahydro-pyrido(3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(6,6-dimethyl-bicyclo[3.1.1]hept-
2-en-2-ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-
amide;
Adamantane-1-carboxylic acid [7-(3-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-dimethylamino-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-phenoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-6-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-butyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid (7-ethyl-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(1-methyl-1H-indol-3-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-ethyl-butyl)-5,6,7,8-tetrahydro-
pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-methyl-pentyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-methyl-butyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,4-dimethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-chloro-3,4-dimethoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(6-bromo-benzo[1,3]dioxol-5-
ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide
Adamantane-1-carboxylic acid [7-(4-benzyloxy-3-methoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,3-dihydro-benzo[1,4]dioxin-6-
ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,4-dichloro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,3-dimethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-benzyloxy-4-methoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-hydroxy-4-methoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-bromo-4,5-dimethoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-cyano-4-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid (7-benzo[1,3]dioxol-4-ylmethyl-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(4-bromo-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-chloro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(6-chloro-benzo[1,3]dioxol-5-
ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,2-dimethyl-propyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-chloro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-methyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide
Adamantane-1-carboxylic acid [7-(4-cyano-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-trifluoromethyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-methyl-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,4-dimethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,4-difluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-pyridin-4-ylmethyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(4-chloro-3-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-fluoro-4-trifluoromethyl-
benzyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(6-bromo-pyridin-3-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-bromo-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-methoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-acetylamino-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-bromo-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide
Adamantane-1-carboxylic acid [7-(5-bromo-2-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide
Adamantane-1-carboxylic acid (7-cyclopentylmethyl-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide;
Adamantane-1-carboxylic acid [7-(4-trifluoromethoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-difluoromethoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid {7-[4-(4-fluoro-benzyloxy)-benzyl]-
5,6,7,8-tetrahydro-pyrido[3-4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid [7-(2-fluoro-4,5-dimethoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,6-difluoro-4-methoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-ethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide
Adamantane-1-carboxylic acid {7-[3-(3-trifluoromethyl-phenoxy)-
benzyl]-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl}-amide;
Adamantane-1-carboxylic acid [7-(2,2-difluoro-benzo[1,3]dioxol-5-
ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2-fluoro-5-methoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-fluoro-3-methoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(4-ethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(2,5-dimethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3-trifluoromethoxy-benzyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(3,5-dimethoxy-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide;
Adamantane-1-carboxylic acid [7-(6-chloro-pyridin-3-ylmethyl)-
5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amide; and
Adamantane-1-carboxylic acid [7-(4-chloro-2-fluoro-benzyl)-5,6,7,8-
tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-amide.