Antiviral activity from medicinal mushrooms
Compounds having unique antiviral properties are prepared from medicinal mushroom mycelium, extracts and derivatives. The compositions are derived from Fomitopsis, Piptoporus, Ganoderma and blends of medicinal mushroom species and are useful in preventing and treating viruses including Orthopox viruses, influenza, avian influenza, Venezuelan Equine Encephalitis, yellow fever, West Nile, Dengue, New World and Old World arenaviruses, hantavirus, Rift Valley fever, sandfly fever, hantavirus, SARS, Rhinovirus and other viruses.
1 . A method for preventing, treating, ameliorating, mitigating, alleviating, reducing and curing infection from a virus comprising administering a therapeutically effective amount of a medicinal mushroom derivative wherein the medicinal mushroom is a Fomitopsis and the medicinal mushroom derivative is selected from the group consisting of live mycelium, dried live mycelium, freeze dried mycelium, extracts of live mycelium, solvent free extracts of live mycelium and combinations thereof.
2 . The method of claim 1 wherein the virus is selected from the group consisting of influenza viruses, avian influenza viruses, Venezuelan Equine Encephalitis, West Nile virus, Dengue virus, yellow fever virus, New World and Old World arenaviruses, hantavirus, Rift Valley fever virus, sandfly fever viruses and Rhinoviruses.
3 . The method of claim 1 wherein the virus is selected from the group consisting of Orthomyxoviridae, Alphavirus, Flavivirus, Arenavirus, Phlebovirus and Coronavirus viruses.
4 . The method of claim 1 wherein the Fomitopsis is Fomitopsis officinalis.
5 . The method of claim 1 wherein the Fomitopsis is Fomitopsis pinicola.
6 . The method of claim 1 wherein the Fomitopsis is selected from the group consisting of F. africana, F. albomarginata var. pallida, F. albomarginata var. polita, F. albomarginata var. subvillosa, F. anhuiensis, F. annosaf multistriata, F. annosa var. indica, F. arbitraria, F. avellanea, F. bucholtzii, F. cajanderi, F. caliginosa, F. castanea, F. cinerea, F. concava, F. connata, F. corrugata, F. cuneata, F. cupreorosea, F. cystina, F. cytisina, F. dochmia, F. durescens, F. epileucina, F. euosma, F. feei, F. fulviseda, F. hainaniana, F. iberica, F. ibericus, F. kiyosumiensis, F. komatsuzakii, F. labyrinthica, F. latissima, F. lignea, F. lilacinogilva, F. maackiae, F. maire, F. marginata, F. mellea, F. minutispora, F. nigrescens, F. nivosa, F. odoratissima, F. officinalis (= Laricifomes officinalis ), F. olivacea, F. palustris, F. pinicola, F. pinicola f. effusa, F. pinicola f. paludosa, F. pinicola f. resupinata, F. pseudopetchiin, F. pubertatis, F. quadrans, F. rhodophaea, F. rosea, F. roseozonata, F. rubidus, F. rufolaccata, F. rufopallida, F. sanmingensis, F. scalaris, F. semilaccata, F. sensitiva, F. spraguei, F. stellae, F. subrosea, F. subungulata, F. sulcata, F. sulcata, F. supina, F. unita, F. unita var. lateritia, F. unita var. multistratosa, F. unita var. prunicola, F. vinosa, F. widdringtoniae, F. zonalis and F. zuluensis
7 . The method of claim 1 wherein the live mycelium is grown on a grain.
8 . The method of claim 1 wherein the live mycelium is grown on wood.
9 . The method of claim 1 wherein the medicinal mushroom derivative is administered in a form selected from the group consisting of orally-active powders, pills, capsules, teas, extracts, dried extracts, sublinguals, sprays, dispersions, solutions, suspensions, emulsions, foams, syrups, lotions, ointments, gels, pastes, dermal patches, injectables, vaginal creams and suppositories.
10 . The method of claim 1 wherein the extracts are extracted with ethanol and water.
11 . The method of claim 1 wherein the extracts are extracted with a solvent selected from the group consisting of water, steam, alcohols, organic solvents, carbon dioxide and combinations thereof.
12 . The method of claim 11 wherein the organic solvent is selected from the group consisting of alcohols containing from 1 to 10 carbon atoms, unsubstituted organic solvents containing from 1 to 16 carbon atoms, ketones containing from 3 to 13 carbon atoms, ethers containing from 2 to 15 carbon atoms, esters containing from 2 to 18 carbon atoms, nitrites containing from 2 to 12 carbon atoms, amides containing from 1 to 15 carbon atoms, amines and nitrogen-containing heterocycles containing from 1 to 10 carbon atoms, halogen substituted organic solvents containing from 1 to 14 carbon atoms, acids containing from 1 to 10 carbon atoms, and alkoxy, aryloxy, cyloalkyl, aryl, alkaryl and aralkyl substituted organic solvents containing from 3 to 13 carbon atoms, DMSO and combinations thereof.
13 . The method of claim 1 wherein the medicinal mushroom derivative is added to an animal feed.
14 . The method of claim 1 wherein the medicinal mushroom derivative is added to a food.
15 . The method of claim 14 wherein the medicinal mushroom derivative additionally comprises a derivative selected from the group consisting of Piptoporus betulinus derivatives and Ganoderma resinaceum derivatives.
16 . The method of claim 1 wherein the medicinal mushroom derivative additionally comprises a derivative selected from the group consisting of Piptoporus betulinus derivatives and Ganoderma resinaceum derivatives.
17 . The method of claim 1 wherein marketing of the medicinal mushroom derivative is improved by the claims herein.
18 . A method for preventing, treating, ameliorating, mitigating, alleviating, reducing and curing infection from a virus comprising administering a therapeutically effective amount of a medicinal mushroom derivative wherein the virus is selected from the group consisting of influenza viruses, avian influenza viruses, Venezuelan Equine Encephalitis, West Nile virus, Dengue virus, yellow fever virus, New World and Old World arenaviruses, hantavirus, Rift Valley fever virus, sandfly fever viruses and Rhinoviruses, the medicinal mushroom is a Fomitopsis and the medicinal mushroom derivative is selected from the group consisting of live mycelium, dried live mycelium, freeze dried mycelium, extracts of live mycelium, solvent free extracts of live mycelium and combinations thereof.