Nanoparticulate corticosteroid and antihistamine formulations methods of making, and methods of administering thereof
View Patent ↗Compositions comprising a nanoparticulate corticosteroid and an antihistamine are described. The compositions are useful in the prophylaxis and chronic treatment of asthma in adults and pediatric patients and for the relief of allergic conjunctivitis, symptoms of seasonal allergic rhinitis in adults and pediatric patients. Combining an antihistamine with a nanoparticulate corticosteroid in a single formulation results in improved efficacy.
1. A composition comprising: (a) at least one non-nanoparticulate azelastine; (b) at least one corticosteroid having an effective average particle size of less than 2000 nm; and (c) at least one surface stabilizer; wherein the azelastine is present at 0.1% (w/w) of the composition and the corticosteroid is present at 1% (w/w) of the composition, and wherein the corticosteroid is selected from the group consisting of triamcinolone, budesonide and fluticasone.
2. The composition of claim 1 , wherein the corticosteroid is triamcinolone, and the surface stabilizer comprises hydroxypropylmethyl cellulose and docusate sodium.
3. The composition of claim 1 , wherein the corticosteroid is budesonide, and the surface stabilizer comprises polysorbate 80.
4. The composition of claim 1 , wherein the corticosteroid is fluticasone, and the surface stabilizer comprises povidone and sodium lauryl sulfate.
5. A composition comprising: (a) at least one non-nanoparticulate azelastine; (b) at least one corticosteroid having an effective average particle size of less than 2000 nm; and (c) at least one surface stabilizer; wherein the corticosteroid is triamcinolone, and wherein the composition comprises 1% azelastine and 1% triamcinolone (w/w), or 0.1% azelastine and 1% triamcinolone (w/w).
6. The composition of claim 5 , wherein the surface stabilizer comprises hydroxypropylmethyl cellulose and docusate sodium.
7. A composition comprising: (a) at least one non-nanoparticulate azelastine; (b) at least one corticosteroid having an effective average particle size of less than 2000 nm; and (c) at least one surface stabilizer; wherein the corticosteroid is budesonide, and wherein the composition comprises amounts of azelastine and budesonide selected from the group consisting of: 1% azelastine and 1% budesonide (w/w), 0.1% azelastine and 0.1% budesonide (w/w), and 0.1% azelastine and 1% budesonide (w/w).
8. The composition of claim 7 , wherein the surface stabilizer comprises polysorbate 80.
9. A composition comprising: (a) at least one non-nanoparticulate azelastine; (b) at least one corticosteroid having an effective average particle size of less than 2000 nm; and (c) at least one surface stabilizer; wherein the corticosteroid is fluticasone, and wherein the composition comprises amounts of azelastine and fluticasone selected from the group consisting of: 1% azelastine and 0.1% fluticasone (w/w), 0.1% azelastine and 1% fluticasone (w/w), and 0.1% azelastine and 0.1% fluticasone (w/w).
10. The composition of claim 9 wherein the surface stabilizer comprises povidone and sodium lauryl sulfate.
11. The composition of claim 1 , claim 5 , claim 7 or claim 9 , wherein the corticosteroid particles have a size selected from the group consisting of less than 1900 nm, less than 1800 nm, less than 1700 nm, less than 1600 nm, less than 1500 nm, less than 1400 nm, less than 1300 nm, less than 1200 nm, less than 1100 nm, less than 1000 nm, less than 900 nm, less than 800 nm, less than 700 nm, less than 650 nm, less than 600 nm, less than 550 nm, less than 500 nm, less than 450 nm, less than 400 nm, less than 350 nm, less than 300 nm, less than 250 nm, less than 200 nm, less than 150 nm, less than 100 nm, less than 75 nm, and less than 50 nm.
12. The composition of claim 1 , claim 5 , claim 7 or claim 9 , wherein the composition further comprises one or more pharmaceutically acceptable excipients, carriers, or a combination thereof.
13. The composition of claim 1 , claim 5 , claim 7 or claim 9 , formulated into an aerosol dosage form, wherein the composition is suitable for aerosol administration of the azelastine and corticosteroid dosage in about 15 seconds or less.
14. The composition of claim 1 , claim 5 , claim 7 or claim 9 , formulated into an aerosol dosage form and further comprising a propellant that is administered from a multi-dose inhaler.
15. The composition of claim 1 , claim 5 , claim 7 or claim 9 , formulated into an aerosol dosage form, wherein the aerosol is formed from a liquid dispersion of droplets comprising the composition and the droplets have a mass median aerodynamic diameter selected from the group consisting of less than or equal to 100 microns, about 30 to about 60 microns, about 0.1 to about 10 microns, about 2 to about 6 microns, and less than 2 microns.
16. The composition of claim 1 , claim 5 , claim 7 or claim 9 , formulated into an aerosol dosage form, wherein the aerosol is formed from a dry powder of aggregates of the composition, wherein the aggregates have a mass median aerodynamic diameter selected from the group consisting of less than or equal to 100 microns, about 30 to about 60 microns, about 0.1 to about 10 microns, about 2 to about 6 microns, and less than 2 microns.
17. A method of making an antihistamine and nanoparticulate corticosteroid composition comprising the steps of: (a) contacting particles of at least one corticosteroid with at least one surface stabilizer for a time and under conditions sufficient to provide a corticosteroid composition having an effective average particle size of less than 2,000 nm; and (b) adding at least one non-nanoparticulate antihistamine to the composition, wherein following addition of the antihistamine the corticosteroid retains an effective average particle size of less than 2000 nm; wherein the antihistamine is azelastine; wherein the azelastine is present at 0.1% (w/w) of the composition and the corticosteroid is present at 1% (w/w) of the composition; and wherein the corticosteroid is selected from the group consisting of triamcinolone, budesonide and fluticasone.
18. A method of making an antihistamine and nanoparticulate corticosteroid composition comprising the steps of: (a) contacting particles of at least one corticosteroid with at least one surface stabilizer for a time and under conditions sufficient to provide a corticosteroid composition having an effective average particle size of less than 2,000 nm; and (b) adding at least one non-nanoparticulate antihistamine to the composition, wherein following addition of the antihistamine the corticosteroid retains an effective average particle size of less than 2000 nm; wherein the antihistamine is azelastine, wherein the corticosteroid is triamcinolone, and wherein the composition comprises 1% azelastine and 1% triamcinolone (w/w), or 0.1% azelastine and 1% triamcinolone (w/w).
19. A method of making an antihistamine and nanoparticulate corticosteroid composition comprising the steps of: (a) contacting particles of at least one corticosteroid with at least one surface stabilizer for a time and under conditions sufficient to provide a corticosteroid composition having an effective average particle size of less than 2,000 nm; and (b) adding at least one non-nanoparticulate antihistamine to the composition, wherein following addition of the antihistamine the corticosteroid retains an effective average particle size of less than 2000 nm; wherein the antihistamine is azelastine, wherein the corticosteroid is budesonide, and wherein the composition comprises amounts of antihistamine and corticosteroid selected from the group consisting of: 1% azelastine and 1% budesonide (w/w), 0.1% azelastine and 0.1% budesonide (w/w), and 0.1% azelastine and 1% budesonide (w/w).
20. A method of making an antihistamine and nanoparticulate corticosteroid composition comprising the steps of: (a) contacting particles of at least one corticosteroid with at least one surface stabilizer for a time and under conditions sufficient to provide a corticosteroid composition having an effective average particle size of less than 2,000 nm; and (b) adding at least one non-nanoparticulate antihistamine to the composition, wherein following addition of the antihistamine the corticosteroid retains an effective average particle size of less than 2000 nm; wherein the antihistamine is azelastine, wherein the corticosteroid is fluticasone, and wherein the composition comprises amounts of antihistamine and corticosteroid selected from the group consisting of: 1% azelastine and 0.1% fluticasone (w/w), 0.1% azelastine and 1% fluticasone (w/w), and 0.1% azelastine and 0.1% fluticasone (w/w).
21. A method of administering to a patient in need thereof an antihistamine/nanoparticulate corticosteroid composition, comprising administering to the patient a therapeutically effective amount of a composition comprising: (a) at least one non-nanoparticulate azelastine; (b) at least one nanoparticulate corticosteroid having an effective average particle size of less than 2000 nm; and (c) at least one surface stabilizer; wherein the azelastine is present at 0.1% (w/w) of the composition and the corticosteroid is present at 1% (w/w) of the composition, and wherein the corticosteroid is selected from the group consisting of triamcinolone, budesonide and fluticasone.
22. A method of administering to a patient in need thereof an antihistamine/nanoparticulate corticosteroid composition, comprising administering to the patient a therapeutically effective amount of a composition comprising: (a) at least one non-nanoparticulate azelastine; (b) at least one nanoparticulate corticosteroid having an effective average particle size of less than 2000 nm; and (c) at least one surface stabilizer; wherein the corticosteroid is triamcinolone, and wherein the composition comprises 1% azelastine and 1% triamcinolone (w/w), or 0.1% azelastine and 1% triamcinolone (w/w).
23. A method of administering to a patient in need thereof an antihistamine/nanoparticulate corticosteroid composition, comprising administering to the patient a therapeutically effective amount of a composition comprising: (a) at least one non-nanoparticulate azelastine; (b) at least one nanoparticulate corticosteroid having an effective average particle size of less than 2000 nm; and (c) at least one surface stabilizer; wherein the corticosteroid is budesonide, and wherein the composition comprises amounts of antihistamine and corticosteroid selected from the group consisting of: 1% azelastine and 1% budesonide (w/w), 0.1% azelastine and 0.1% budesonide (w/w), and 0.1% azelastine and 1% budesonide (w/w).
24. A method of administering to a patient in need thereof an antihistamine/nanoparticulate corticosteroid composition, comprising administering to the patient a therapeutically effective amount of a composition comprising: (a) at least one non-nanoparticulate azelastine; (b) at least one nanoparticulate corticosteroid having an effective average particle size of less than 2000 nm; and (c) at least one surface stabilizer; wherein the corticosteroid is fluticasone, and wherein the composition comprises amounts of antihistamine and corticosteroid selected from the group consisting of: 1% azelastine and 0.1% fluticasone (w/w), 0.1% azelastine and 1% fluticasone (w/w), and 0.1% azelastine and 0.1% fluticasone (w/w).