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Patent Application
App. No. 11/387,074

Detection of genetic polymorphisms

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Patent No.
US None
App. No.
11/387,074
Abstract

The present invention relates to genetic polymorphism data, compositions and methods for detecting genetic polymorphisms, methods for evaluating drugs using genetic polymorphisms and screening methods for drugs.

Claims (22)

1 . A method of genotyping a subject, comprising;

a. providing nucleic acid from a subject; and

b. detecting the presence of at least one polymorphism in said nucleic acid, said at least one polymorphism selected from the group consisting of polymorphisms found in SEQ ID NOs:1-7669.

2 . The method of claim 1 , further comprising step c) providing a prognosis to said subject based on the presence or absence of said at least one polymorphism.

3 . The method of claim 2 , wherein said prognosis comprises a genotype relative risk.

4 . The method of claim 2 , wherein said prognosis comprises a population attributable risk.

5 . The method of claim 1 , wherein said detecting step comprises use of a hybridization assay.

6 . The method of claim 1 , wherein said detecting step comprises use of a TAQMAN assay.

7 . The method of claim 1 , wherein said detecting step comprises use of an invasive cleavage assay.

8 . The method of claim 1 , wherein said detecting step comprises use of mass spectroscopy.

9 . The method of claim 5 , wherein said hybridization assay is selected from the group consisting of a microarray assay or a bead array assay.

10 . The method of claim 1 , wherein said detecting step comprises use of a polymerase chain reaction.

11 . The method of claim 1 , wherein said detecting step comprises use of a rolling circle extension assay.

12 . The method of claim 1 , wherein said detecting step comprises use of a hybridization assay employing a probe complementary to a polymorphism.

13 . The method of claim 1 , wherein said detecting step comprises use of a primer extension assay.

14 . The method of claim 1 , wherein said detecting step comprises use of an enzyme mismatch cleavage assay.

15 . The method of claim 1 , wherein said detecting step comprises use of a branched hybridization assay.

16 . The method of claim 1 , wherein said detecting step comprises use of a NASBA assay.

17 . The method of claim 1 , wherein said detecting step comprises use of a molecular beacon assay.

18 . The method of claim 1 , wherein said detecting step comprises use of a cycling probe assay.

19 . The method of claim 1 , wherein said detecting step comprises use of a ligase chain reaction assay.

20 . The method of claim 1 , wherein said detection step comprises use of a sandwich hybridization assay.

Assignments (2)
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 26, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024892/0001 →
THIRD SUPPLEMENT TO PATENT SECURITY AGREEMENT Recorded Dec 1, 2008
From: THIRD WAVE TECHNOLOGIES, INC.
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 021907/0076 →