Methods and formulations for delivery of pharmacologically active agents
In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of a pharmaceutically active agent, wherein the agent is associated with a polymeric biocompatible material.
1 . A method for the delivery of a substantially water insoluble pharmacologically active agent to a subject in need thereof by inhalation, said method comprising:
administering an effective amount of the agent in the form of particles to the subject, wherein the particles comprise the agent and a protein shell.
2 . The method according to claim 1 wherein the protein is albumin.
3 . The method according to claim 1 , wherein the agent is cyclosporine.
4 . The method according to claim 1 , wherein the agent is a taxane.
5 . The method according to claim 4 , wherein the protein is albumin.
6 . The method according to claim 4 , wherein the taxane is paclitaxel.
7 . The method according to claim 6 , wherein the protein is albumin.
8 . The method according to claim 4 , wherein the taxane is a paclitaxel analog.
9 . The method according to claim 4 , wherein the taxane is docetaxel.
10 . The method according to claim 9 , wherein the protein is albumin.
11 . The method according to claim 1 , wherein the protein is substantially crosslinked by way of disulfide bonds.
12 . The method according to claim 11 , wherein the protein is albumin.
13 . The method according to claim 11 , wherein the agent is cyclosporine.
14 . The method according to claim 11 , wherein the agent is a taxane.
15 . The method according to claim 14 , wherein the protein is albumin.
16 . The method according to claim 14 , wherein the taxane is paclitaxel.
17 . The method according to claim 16 , wherein the protein is albumin.
18 . The method according to claim 14 , wherein the taxane is a paclitaxel analog.
19 . The method according to claim 14 , wherein the taxane is docetaxel.
20 . The method according to claim 19 , wherein the protein is albumin.
21 . The method according to claim 8 , wherein the protein is albumin.
22 . The method according to claim 18 , wherein the protein is albumin.
23 . The method according to claim 1 , wherein the agent is solid or liquid.