Topical acne vulgairs medication with a sunscreen
View Patent ↗Increased compliance in the use of topical sunscreens is obtained by combining a topical sunscreen agent in a formulation containing an antibacterial medication such as azelaic acid or an antibiotic.
1. A photostable, chemically stable, and physically stable formulation for topical application to the skin for treating acne vulgaris and protecting skin from harmful effects of chronic exposure to the sun comprising a vehicle, one or more sunscreen agents dissolved or suspended in the vehicle, which sunscreen agent is selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, anisotriazine, para-aminobenzoic acid (PABA) and derivatives, anthranilates, benzophenones, cinnamates, salicylates, camphor derivatives, benzene 1,4-di(3-methylidene-10-camphosulfonic) acid, drometriazole trisiloxane, and dibenzoylmethanes, and an antibiotic medication of the macrolide or lincomycin family that is effective in treating or reducing the signs of acne vulgaris, which antibiotic medication is dissolved or suspended in the vehicle.
2. The formulation of claim 1 wherein the antibiotic medication is clindamycin.
3. The formulation of claim 1 wherein the sunscreen agent is selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, and anisotriazine.
4. The formulation of claim 2 wherein the sunscreen agent is selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, and anisotriazine.
5. The formulation of claim 1 which further comprises an antioxidant.
6. The formulation of claim 2 which further comprises an antioxidant.
7. The formulation of claim 3 which further comprises an antioxidant.
8. The formulation of claim 4 which further comprises an antioxidant.
9. The formulation of claim 1 wherein the vehicle contains one or more of water, alcohol, or propylene glycol.
10. The formulation of claim 1 which is free of emulsifying agents.
11. The formulation of claim 1 which is a gel.
12. The formulation of claim 11 which contains a carbomer gelling agent.
13. The formulation of claim 1 which contains no other sunscreen agent other than those selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, anisotriazine, para-aminobenzoic acid (PABA) and derivatives, anthranilates, benzophenones, cinnamates, salicylates, camphor derivatives, benzene 1,4-di(3-methylidene-10-camphosulfonic) acid, drometriazole trisiloxane, and dibenzoylmethanes.
14. The formulation of claim 1 which is non-comedogenic.
15. A method for making a photostable, chemically stable, and physically stable formulation for topical application to the skin for concomitantly treating acne vulgaris and protecting skin from harmful effects of chronic exposure to the sun comprising dissolving or suspending in a vehicle one or more sunscreen agents selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, anisotriazine, para-aminobenzoic acid (PABA) and derivatives, anthranilates, benzophenones, cinnamates, salicylates, camphor derivatives, benzene 1,4-di(3-methylidene-10-camphosulfonic) acid, drometriazole trisiloxane, and dibenzoylmethanes, and dissolving or suspending in the vehicle an antibiotic medication of the macrolide or lincomycin family that is effective in treating or reducing the signs of acne vulgaris.
16. The method of claim 15 wherein the antibiotic medication is clindamycin.
17. The method of claim 15 wherein the sunscreen agent is selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, and anisotriazine.
18. The method of claim 16 wherein the sunscreen agent is selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, and anisotriazine.
19. The method of claim 15 which further comprises combining an antioxidant in the vehicle.
20. The method of claim 16 which further comprises combining an antioxidant in the vehicle.
21. The method of claim 17 which further comprises combining an antioxidant in the vehicle.
22. The method of claim 18 which further comprises combining an antioxidant in the vehicle.
23. The method of claim 15 wherein the vehicle contains one or more of water, alcohol, or propylene glycol.
24. The method of claim 15 wherein an emulsifying agent is not combined in the vehicle.
25. The method of claim 15 wherein a gelling agent is combined in the vehicle.
26. The method of claim 25 wherein the gelling agent is a carbomer.
27. The method of claim 15 wherein no sunscreen agent other than those selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, anisotriazine, para-aminobenzoic acid (PABA) and derivatives, anthranilates, benzophenones, cinnamates, salicylates, camphor derivatives, benzene 1,4-di(3-methylidene-10-camphosulfonic) acid, drometriazole trisiloxane, and dibenzoylmethanes is dissolved or suspended in the vehicle.
28. The method of claim 15 wherein the formulation is non-comedogenic.
29. A method for concomitantly treating, preventing, or reducing the signs of acne vulgaris and protecting skin from ultraviolet radiation comprising applying to the skin a photostable, chemically stable, and physically stable formulation comprising a vehicle, one or more sunscreen agents dissolved or suspended in the vehicle, which sunscreen agent is selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, anisotriazine, para-aminobenzoic acid (PABA) and derivatives, anthranilates, benzophenones, cinnamates, salicylates, camphor derivatives, benzene 1,4-di(3-methylidene-10-camphosulfonic) acid, drometriazole trisiloxane, and dibenzoylmethanes, and an antibiotic medication of the macrolide or lincomycin family that is effective in treating or reducing the signs of acne vulgaris, which antibiotic medication is dissolved or suspended in the vehicle.
30. The method of claim 29 wherein the antibiotic medication is clindamycin.
31. The method of claim 29 wherein the sunscreen agent is selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, and anisotriazine.
32. The method of claim 30 wherein the sunscreen agent is selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, and anisotriazine.
33. The method of claim 29 wherein the formulation further comprises an antioxidant.
34. The method of claim 30 wherein the formulation further comprises an antioxidant.
35. The method of claim 31 wherein the formulation further comprises an antioxidant.
36. The method of claim 32 wherein the formulation further comprises an antioxidant.
37. The method of claim 29 wherein the vehicle contains one or more of water, alcohol, or propylene glycol.
38. The method of claim 29 wherein the formulation is free of emulsifying agents.
39. The method of claim 29 wherein the formulation is a gel.
40. The method of claim 39 wherein the formulation contains a carbomer gelling agent.
41. The method of claim 29 wherein the formulation contains no other sunscreen agent other than those selected from the group consisting of titanium dioxide, zinc oxide, bisoctrizole, anisotriazine, para-aminobenzoic acid (PABA) and derivatives, anthranilates, benzophenones, cinnamates, salicylates, camphor derivatives, benzene 1,4-di(3-methylidene-10-camphosulfonic) acid, drometriazole trisiloxane, and dibenzoylmethanes.
42. The method of claim 29 wherein the formulation is non-comedogenic.