Antifungal and antiparasitic indoloquinoline derivates
View Patent ↗An indoloquinoline wherein the quarternary N-5 atom is a straight C(1-5) chain, a branched C(1-5) chain, a heteroatom chain, a straight chain substituted terminally by a cycloalkyl or aromatic ring, a branched chain substituted terminally by a cycloalkyl or aromatic ring, a heteroatom chain substituted terminally by a cycloalkyl or aromatic ring; the 10 position is N—R 10 , O, S, S═O, CH 2 , or C═O, where R 10 is a branched C(1-5) chain, a heteroatom chain, a straight chain substituted terminally by a cycloalkyl or aromatic ring, a branched chain substituted terminally by a cycloalkyl or aromatic ring, a heteroatom chain substituted terminally by a cycloalkyl or aromatic ring. In one embodiment the quarternary N-5 atom is —CH 3 and the 10 position is N—(CH 2 ) 5 —Ph.
1. A compound having the formula:
wherein:
R 5 is —CH 3 ; and
Z is N—(CH 2 ) 5 —Ph.
2. The compound of claim 1 , wherein said compound is a quaternary salt.
3. A pharmaceutical composition comprising a pharmacologically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
4. The pharmaceutical composition of claim 3 comprising a pharmacologically antimycobacterial, antimalarial, or antifungal effective amount of a compound and a pharmaceutically acceptable carrier.
5. A method of treating a mammal in need of antimycobacterial, antimalarial, or antifungal therapy comprising administering thereto a pharmacologically effective amount of a compound of claim 1 .
6. An article of manufacture comprising packaging material and a pharmaceutical agent contained within said packaging material, wherein said pharmaceutical agent is effective for the treatment of a subject suffering from one or more of conditions of a fungal infection, a mycobacterial infection, or malaria, and wherein said packaging material comprises a label which indicates that said pharmaceutical agent can be used for ameliorating the symptoms associated with said condition and wherein said pharmaceutical agent is a compound of claim 1 .
7. The compound of claim 2 wherein said quaternary salt has the formula:
wherein: X is an anion, wherein X is I or tosylate.