Pharmaceutically active compounds and methods of use

1. A method of treating chronic pain in a mammal which method comprises administering to a mammal, in need thereof, a therapeutically effective amount of a fused thiophene compound of the Formula:

wherein

R 1 , R 2 , R 3 , and R 4 are independently hydrogen, halogen, cyano, amino, nitro, thio, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted alkylamino, optionally substituted dialkylamino, optionally substituted alkylthio, optionally substituted alkylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkanoyl, optionally substituted carbocyclic aryl, or an optionally substituted heteroalicyclic or heteroaromatic;

R 5 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclic aryl, or an optionally substituted heteroalicyclic or heteroaromatic;

each R 6 is hydrogen;

R 9 and R 10 are independently hydrogen or hydroxyl, or together may represent a carbonyl oxygen;

wherein said heteroalicyclic is a monovalent saturated or unsaturated carbocyclic group having a single ring or multiple condensed rings, from 1 to 15 carbon atoms and from 1 to 5 heteroatoms within the ring or rings selected from the group of heteroatoms consisting of nitrogen, sulfur, and oxygen;

wherein said heteroaromatic is a 5-membered or 6-membered heterocyclic, aromatic group, which can optionally be fused to an aryl or substituted aryl ring or fused to a second or third heteroaromatic group;

or a pharmaceutically acceptable salt thereof.

2. The method according to claim 1 wherein the chronic pain is neuropathic pain.

3. The method according to claim 2 wherein the mammal is a human.

4. The method according to claim 1 wherein the fused thiophene compound of Formula (I) is having the Formula:

wherein

X and X 1 are independently H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted carbocyclic aryl, nitro or halogen,

X 2 is amino;

or a pharmaceutically acceptable salt thereof.

5. The method according to claim 4 wherein the chronic pain is neuropathic pain.

6. The method according to claim 5 wherein the mammal is a human.

7. The method according to claim 1 wherein the fused thiophene compound of Formula (I) is selected from the group consisting of:

1-amino-8H-indeno[1,2-c]thiophen-8-one;

1-amino-5-chloro-8H-indeno[1,2-c]thiophen-8-one;

1-amino-5-methyl-8H-indeno[1,2-c]thiophen-8-one;

1-amino-4,5-dichloro-8H-indeno[1,2-c]thiophen-8-one;

1-amino-4,5-dimethyl-8H-indeno[1,2-c]thiophen-8-one;

1-amino-5-ethyl-8H-indeno[1,2-c]thiophen-8-one;

1-amino-5-propyl-8H-indeno[1,2-c]thiophen-8-one;

1-amino-7-methyl-2-thia-cyclopenta[a]inden-8-one;

1-amino-7-chloro-2-thia-cyclopenta[a]inden-8-one;

1-amino-6,7-dichloro-2-thia-cyclopenta[a]inden-8-one;

1-amino-5,6-dichloro-2-thia-cyclopenta[a]inden-8-one;

1-amino-4-chloro-2-thia-cyclopenta[a]inden-8-one;

1-amino-6-chloro-2-thia-cyclopenta[a]inden-8-one;

1-amino-4-methyl-2-thia-cyclopenta[a]inden-8-one;

1-amino-6-methyl-2-thia-cyclopenta[a]inden-8-one;

1-amino-6-ethyl-2-thia-cyclopenta[a]inden-8-one;

1-amino-4-methoxy-2-thia-cyclopenta[a]inden-8-one;

1-amino-5-methoxy-2-thia-cyclopenta[a]inden-8-one;

1-amino-7-methoxy-2-thia-cyclopenta[a]inden-8-one;

1-amino-6-methoxy-2-thia-cyclopenta[a]inden-8-one;

and

1,6-diamino-2-thia-cyclopenta[a]inden-8-one;

or a pharmaceutically acceptable salt thereof.

8. The method according to claim 7 wherein the chronic pain is neuropathic pain.

9. The method according to claim 8 wherein the mammal is a human.