Compositions of novel opioid compounds and method of use thereof
View Patent ↗Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.
1. A compound of the formula
wherein:
Z is H, O(CH 2 )nCH 3 , wherein n=0 to 4, or OH;
X is —C═O which is on the meta or para position of the phenyl ring;
DL is a group having a nitrogen that is covalently bonded to the carbon atom of group X;
R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 cycloalkylmethyl, arylalkyl having C 5 -C 10 aryl and C 1 -C 6 alkyl moieties, halobenzyl or carboxybenzyl; and
wherein the DL is selected from the group consisting of: