Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
View Patent ↗Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
1. A pharmaceutical composition comprising:
(a) a cyclodextrin; and (b) a glycopeptide antibiotic or a pharmaceutically acceptable salt thereof; wherein the glycopeptide antibiotic has the formula:
Wherein R 20 is a lipid substituent containing from 10 to 40 carbon atoms, and optionally containing heteroatoms selected from halo, oxygen, nitrogen, sulfur and phosphorous; and wherein R 19 is hydrogen, and R 5 is a substituent of the formula: —CH 2 —NH—R a —P(O)(OH) 2 wherein R a is alkylene.
2. The pharmaceutical composition of claim 1 , wherein the cyclodextrin is hydroxypropyl-β-cyclodextrin.
3. The pharmaceutical composition of claim 1 , wherein the cyclodextrin is sulfobutyl ether β-cyclodextrin.
4. The pharmaceutical composition of claim 1 , wherein the composition is a lyophilized powder.
5. The pharmaceutical composition of claim 1 , wherein the cyclodextrin comprises about 1 to 40 weight percent of the composition.
6. The pharmaceutical composition of claim 1 , wherein the glycopeptide antibiotic is in the form of a pharmaceutically acceptable salt.
7. The pharmaceutical composition of claim 1 , wherein the glycopeptide antibiotic is in the form of a hydrochloride salt.