Vaccines containing ribavirin and methods of use thereof
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising ribavirin and an antigen, preferably an antigen that has an epitope present in Hepatitis C virus (HCV), are disclosed for use in treating and preventing disease, preferably HCV infection.
1. A method of enhancing the production of hepatitis-specific antibodies in a subject in need thereof consisting essentially of:
identifying a subject in need of an enhancement of the production of hepatitis-specific antibodies; and
providing, in a single administration, an immunogenic composition that comprises an effective amount of ribavirin and a nucleic acid molecule that encodes a hepatitis antigen to said subject.
2. The method of claim 1 , wherein said hepatitis antigen is a hepatitis C virus (HCV) antigen.
3. The method of claim 1 , wherein said nucleic acid molecule encodes a hepatitis antigen that comprises a hepatitis C virus NS3 protein.
4. The method of claim 1 , wherein said immunogenic composition is formulated for use with an injection device.
5. The method of claim 4 , wherein said injection device is an electrical injection device.
6. The method of claim 4 , wherein said injection device is a needleless injection device.
7. The method of claim 1 , further comprising measuring IgG levels following administration of said immunogenic composition.
8. The method of claim 2 , wherein said immunogenic composition is formulated for use with an injection device.
9. The method of claim 8 , wherein said injection device is an electrical injection device.
10. The method of claim 8 , wherein said injection device is a needleless injection device.
11. The method of claim 2 , further comprising measuring IgG levels following administration of said immunogenic composition.
12. The method of claim 3 , wherein said immunogenic composition is formulated for use with an injection device.
13. The method of claim 12 , wherein said injection device is an electrical injection device.
14. The method of claim 12 , wherein said injection device is a needleless injection device.
15. The method of claim 3 , further comprising measuring IgG levels following administration of said immunogenic composition.
16. The method of claim 1 , wherein said immunogenic composition is provided to said subject intranasally.
17. The method of claim 1 , wherein said immunogenic composition is provided to said subject transdermally.
18. The method of claim 1 , wherein said immunogenic composition comprises an oil.