IP Library Granted Patent US 7,435,588
Granted Patent B2
US 7,435,588 · App. 11/414,439 · Granted Oct 14, 2008

Systems for detection and production of respiratory, herpes and enteric viruses

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Quick Facts
Patent No.
US 7,435,588
App. No.
11/414,439
Granted
Oct 14, 2008
Kind
B2
Abstract

The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.

Claims (13)

1. A method for detecting a virus, comprising:

a) providing a mixed cell culture comprising Calu-3 cells and A549 cells, and a sample suspected of containing a virus;

b) inoculating said mixed cell culture with said sample to produce an inoculated culture; and

c) detecting the presence of said virus in said inoculated culture.

2. The method of claim 1 , wherein said virus is a respiratory virus.

3. The method of claim 2 , wherein said respiratory virus is selected from the group consisting of influenza A virus, influenza B virus, parainfluenza virus 1, parainfluenza virus 2, parainfluenza virus 3, adenovirus, and respiratory syncytial virus.

4. The method of claim 1 , wherein said virus is a herpesvirus.

5. The method of claim 4 , wherein said herpesvirus is selected from the group consisting of herpes simplex type 1, herpes simplex type 2, cytomegalovirus, vermicelli-zoster virus, human herpes virus 6, and human herpes virus 7.

6. The method of claim 4 , wherein said herpesvirus is herpes simplex virus 1 or herpes simplex virus 2.

7. The method of claim 1 , wherein said virus is an enteric virus.

8. The method of claim 7 , wherein said enteric virus is selected from the group consisting of Coxsackie virus, enterovirus, and echovirus.

9. The method of claim 1 , further comprising, providing a monoclonal antibody reactive with a virus selected from the group consisting of a respiratory virus, a herpes virus, and an enteric virus, and wherein step c comprises using said monoclonal antibody for detecting said virus.

10. The method of claim 9 , wherein said monoclonal antibody comprises a fluorescent label.

Assignments (9)
RELEASE (REEL 060220 / FRAME 0711) Recorded Aug 22, 2025
From: BANK OF AMERICA, N.A.
To: QUIDEL CORPORATION; BIOHELIX CORPORATION; DIAGNOSTIC HYBRIDS, INC.; QUIDEL CARDIOVASCULAR INC.; ORTHO-CLINICAL DIAGNOSTICS, INC.; CRIMSON U.S. ASSETS LLC; CRIMSON INTERNATIONAL ASSETS LLC; MICRO TYPING SYSTEMS, INC.
Reel/Frame 072577/0536 →
SECURITY AGREEMENT Recorded Aug 22, 2025
From: CRIMSON INTERNATIONAL ASSETS LLC; MICRO TYPING SYSTEMS, INC.; ORTHO-CLINICAL DIAGNOSTICS, INC.; QUIDEL CARDIOVASCULAR INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 072526/0643 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 15, 2024
From: DIAGNOSTICS HYBRIDS, INC.
To: ORTHO-CLINICAL DIAGNOSTICS, INC.
Reel/Frame 068657/0748 →
SECURITY AGREEMENT Recorded May 31, 2022
From: QUIDEL CORPORATION; BIOHELIX CORPORATION; DIAGNOSTIC HYBRIDS, INC.; QUIDEL CARDIOVASCULAR INC.; ORTHO-CLINICAL DIAGNOSTICS, INC.; CRIMSON U.S. ASSETS LLC; CRIMSON INTERNATIONAL ASSETS LLC; MICRO TYPING SYSTEMS, INC.
To: BANK OF AMERICA, N.A.
Reel/Frame 060220/0711 →
RELEASE OF SECURITY INTEREST Recorded May 31, 2022
From: BANK OF AMERICA, N.A.
To: QUIDEL CORPORATION
Reel/Frame 060220/0649 →
SECURITY INTEREST Recorded Oct 6, 2017
From: QUIDEL CORPORATION
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 044141/0686 →
CHANGE OF NAME Recorded Mar 21, 2017
From: UNIVERSITY HOSPITALS OF CLEVELAND
To: UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER
Reel/Frame 042742/0793 →
CHANGE OF ADDRESS Recorded Jan 12, 2017
From: DIAGNOSTIC HYBRIDS, INC.
To: DIAGNOSTIC HYBRIDS, INC.
Reel/Frame 041351/0846 →
NOTICE OF RELEASE OF GRANT OF PATENT SECURITY INTEREST Recorded Dec 1, 2016
From: BANK OF AMERICA, N.A., AS AGENT
To: DIAGNOSTIC HYBRIDGS, INC.
Reel/Frame 040788/0200 →