Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
View Patent ↗Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.
1. A compound having the formula:
wherein:
L is —O—or —NHCO—;
POLY is poly(ethylene glycol) having a capping group selected from the group consisting of — H , alkoxy, and
wherein L is as described.
2. A compound having the formula:
wherein mPEG is methoxy end-capped poly(ethylene glycol) and L is —O—or —NHCO—.
3. The compound of claim 2 , having the formula:
wherein mPEG is methoxy end-capped poly(ethylene glycol).
4. A compound having the formula:
wherein mPEG is methoxy end-capped poly(ethylene glycol) and L is —O—or —N H CO—.
5. The compound of claim 4 , having the formula:
wherein mPEG is methoxy end-capped poly(ethylene glycol).