Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
An ophthalmic composition is self-emulsifying. The composition includes oil globules having an average size of less than 1 micron dispersed in an aqueous phase. These globules include a surfactant component with one or two surfactants and a polar oil component. The surfactant component and the oil component are selected to self-emulsify when mixed without mechanical homogenization. The composition also includes a disinfectant suitable for ophthalmic use, and can optionally include a therapeutic agent suitable for ophthalmic treatment.
1 . An ophthalmic composition that is self-emulsifying comprising:
(a) oil globules having an average size of less than 1 micron dispersed in an aqueous phase; said globules comprising:
(i) a surfactant component consisting essentially of one or two surfactants; and
(ii) a polar oil component, said surfactant component and said oil component selected to self-emulsify when mixed without mechanical homogenization; and
(b) a disinfectant suitable for ophthalmic use.
2 . The ophthalmic composition of claim 1 , additionally comprising a therapeutic agent suitable for ophthalmic treatment.