Controllable release nasal system
View Patent ↗Embodiments of devices and system for controllable nasal delivery of materials are described. Methods of use of such devices and system and software for controlling the operation of such devices and systems are also disclosed.
1. A controllable release nasal system, comprising:
a structural element including at least one positioning portion configured for contacting an interior surface of a nasal region and mounting the structural element within the nasal region of a subject;
a delivery portion mounted relative to the structural element and configured to release at least one material responsive to a delivery control signal; and
control signal generation circuitry configured to generate a delivery control signal corresponding to a desired pattern of release of the at least one material into the nasal region.
2. The system of claim 1 , wherein the controllable release nasal system is configured to reside entirely within the nasal region of the subject.
3. The system of claim 1 , wherein the structural element includes a self-expanding structure configured to expand to mount the structural element within the nasal region of the subject.
4. The system of claim 1 , wherein the delivery portion is configured to release the at least one material directly into the nasal mucosa for absorption.
5. The system of claim 4 , wherein the delivery portion includes a permeation enhancer capable of increasing the permeation of the at least one material into the nasal mucosa.
6. The system of claim 1 , wherein the delivery portion is configured to release the at least one material into the nasal cavity.
7. The system of claim 6 , wherein the delivery portion is configured to direct the release of the at least one material toward a location selected from the nasal mucosa, the olfactory portion of the nasal mucosa, and the nasopharynx.
8. The system of claim 1 , including a source of the at least one material, the source connected to the delivery portion.
9. The system of claim 8 , wherein the source is located at one of a location in or on the structural element or a location external to the nasal region of the subject and connected to the delivery portion via a delivery tube that enters the nasal region of the subject via a Nostril of the subject.
10. The system of claim 1 , wherein the positioning portion includes at least one of a clip structure, at least a portion of which is configured to extend outside the nasal region of the subject; an adhesive; one or more barb-like structures; a vacuum-generating device; or a hair-engaging structure.
11. The system of claim 1 , wherein at least a part of the structural element is configured for mounting within one of a Nostril of the subject or a nasal cavity of the subject.
12. The system of claim 1 , including:
a power source;
a sensor capable of detecting or measuring a parameter of interest in the nasal region of the subject;
a memory location; and
a source of the at least one material, the source connected to the delivery portion.
13. A method of delivering a material to the nasal region of a subject, comprising:
releasing at least one material from a delivery portion of a delivery device mounted within a nasal region of a subject in response to a delivery control signal corresponding to a desired release pattern.
14. The method of claim 13 , including generating a delivery control signal at least in part as a function of the individual identity of the subject.
15. The method of claim 13 , including releasing at least one material including one or more odorant, aroma, scented material, olfactory modulator, neurotransmitter or neurotransmitter inhibitor.
16. The method of claim 13 , including at least one of mounting at least a portion of the delivery device within the nasal region of the subject or removing at least a portion of the delivery portion of the delivery device from the nasal region of the subject following a use period.