IP Library › Granted Patent US 8,211,874
Granted Patent B2
US 8,211,874 · App. 11/421,615 · Granted Jul 3, 2012

Inhibition of thrombin generation

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,211,874
App. No.
11/421,615
Granted
Jul 3, 2012
Kind
B2
Abstract

The present invention is a method for inhibiting undesirable thrombin generation in a mammal in need thereof. The method comprises administering to the mammal an effective amount of a non-antibacterial tetracycline formulation.

Claims (10)

1. A method for inhibiting undesirable thrombin generation in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a non-antibacterial tetracycline formulation wherein the non-antibacterial tetracycline formulation comprises an antibacterial tetracycline in a sub-antibacterial amount, and the antibacterial tetracycline is doxycycline, minocycline, or tetracycline.

2. A method according to claim 1 , wherein the antibacterial tetracycline is minocycline.

3. A method according to claim 1 , wherein the antibacterial tetracycline is doxycycline.

4. A method according to claim 1 , wherein the mammal is human.

5. A method according to claim 1 , wherein the non-antibacterial tetracycline formulation inhibits the undesirable conversion of prothrombin to thrombin.

6. A method for reducing risk of undesirable thrombin generation in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a non-antibacterial tetracycline formulation, wherein the tetracycline formulation comprises an antibacterial tetracycline in a sub-antibacterial amount, and the antibacterial tetracycline is doxycycline, minocycline, or tetracycline.

7. A method according to claim 6 , wherein the antibacterial tetracycline is minocycline.

8. A method according to claim 6 , wherein the antibacterial tetracycline is doxycycline.

9. A method according to claim 6 , wherein the mammal is human.

10. A method according to claim 6 , wherein the non-antibacterial tetracycline formulation inhibits the undesirable conversion of prothrombin to thrombin.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2011
From: COLLAGENEX PHARMACEUTICALS, INC.
To: GALDERMA LABORATORIES INC.
Reel/Frame 027369/0215 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 5, 2008
From: COLLAGENEX PHARMACEUTICALS, INC.
To: GALDERMA LABORATORIES INC.
Reel/Frame 021328/0949 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 14, 2006
From: THEOBALD, KLAUS; LEVY, JERROLD H.
To: COLLAGENEX PHARMACEUTICALS, INC.
Reel/Frame 018295/0589 →