Modulating apoptosis
View Patent ↗The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-κB activity. The modulators may be used, for example, in the treatment of NF-κB-mediated diseases, conditions, and injuries.
1. A method of protecting a mammal from ionizing radiation sufficient to cause gastrointestinal syndrome or hematopoietic syndrome comprising administering to a mammal in need thereof a composition comprising recombinant flagellin.
2. The method of claim 1 , wherein the composition is administered in combination with a radioprotectant.
3. The method of claim 2 , wherein the radioprotectant is an antioxidant.
4. The method of claim 3 , wherein the antioxidant is selected from the group consisting of amifostine and vitamin E.
5. The method of claim 2 , wherein the radioprotectant is a cytokine.
6. The method of claim 5 , wherein the cytokine is stem cell factor.
7. The method of claim 1 , wherein the composition is administered prior to, together with, or after radiation.
8. The method of claim 1 , wherein the composition is administered in combination with a growth factor.
9. The method of claim 8 , wherein the growth factor is keratinocyte growth factor.
10. The method of claim 1 , wherein the composition is administered in combination with a steroid.
11. The method of claim 10 , wherein the steroid is 5-androstenediol.
12. The method of claim 1 , wherein the composition is administered in combination with ammonium trichloro(dioxoethylene-O,O′)tellurate.
13. The method as in one of claims 1 , 2 - 6 , 7 , or 8 - 12 , wherein the mammal is a human.