Pharmaceutical compositions of drugs and neutralized acidic polymers
View Patent ↗Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed.
1. A pharmaceutical composition, comprising:
(a) a solid amorphous dispersion comprising a low solubility drug and a neutralized acidic enteric polymer, at least 60 wt % of said drug being amorphous, and said drug being dispersed in said polymer;
(b) said low-solubility drug having a solubility in aqueous solution in the absence of said neutralized acidic enteric polymer of less than 1 mg/ml at any pH of from about 1 to about 8; and
(c) said neutralized acidic enteric polymer having a degree of neutralization of at least 0.5.
2. The composition of claim 1 wherein said degree of neutralization of said neutralized acidic enteric polymer is at least 0.9.
3. The composition of claim 1 wherein said degree of neutralization of said neutralized acidic enteric polymer is about 1.
4. The composition of claim 1 wherein said neutralized acidic enteric polymer comprises a counterion selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, ammonium, iron, and amine.
5. The composition of claim 1 wherein said neutralized acidic enteric polymer is selected from the group consisting of a neutralized form of the following polymers: hydroxypropyl methyl cellulose acetate succinate, cellulose acetate phthalate, cellulose acetate trimellitate, hydroxypropyl methyl cellulose phthalate, and carboxymethyl ethyl cellulose.
6. The composition of claim 1 wherein said neutralized acidic enteric polymer is a neutralized form of a polymer selected from the group consisting of carboxylic acid functionalized vinyl polymers, carboxylic acid functionalized polymethacrylates, and carboxylic acid functionalized polyacrylates.
7. The composition of claim 1 wherein said neutralized acidic enteric polymer has a glass transition temperature of at least 40° C.
8. The composition of claim 1 wherein said neutralized acidic enteric polymer is ionically crosslinked with a multivalent cationic species.
9. The composition of claim 8 wherein said multivalent cationic species is selected from the group consisting of calcium, magnesium, aluminum, iron (II), iron (Ill), and a diamine.
10. The composition of claim 1 further comprising a base.
11. The composition of claim 10 wherein said base is selected from the group consisting of sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, aluminum hydroxide, ammonia, ammonium hydroxide, ammonium acetate, sodium acetate, potassium acetate, calcium acetate, magnesium acetate, sodium citrate, trisodium phosphate, disodium phosphate, ethylene diamine, monoethanol amine, diethanol amine, triethanolamine, potassium citrate, sodium carbonate, sodium bicarbonate, sodium acetate, and amine-functional polyacrylates.
12. The composition of claim 10 wherein said base comprises at least 5 wt % of said composition.
13. The composition of claim 1 wherein said drug has an aqueous solubility of less than 0.1 mg/mL.
14. The composition of claim 1 wherein said low solubility drug is acid sensitive.
15. The composition of claim 14 wherein said acid-sensitive drug has at least one functional group selected from the group consisting of sulfonyl ureas, hydroxamic acids, hydroxy amides, carbamates, acetals, hydroxy ureas, esters, and amides.
16. The composition of claim 1 wherein said low-solubility drug and said acidic enteric polymer are in the form of a solid solution.